Pharmacological Activities of Cryptolepis dubia (Burm.f.) M.R.Almeida

Main Article Content

Yollada Sriset
Kanokwan Jarukamjorn
Waranya Chatuphonprasert

Abstract

Cryptolepis buchanani Roem.&Schult. (Thao-en-on), a herbal medicinal plant to a member in the Asclepiadaceae family, has been used in Thai traditional medicine as the treatment of muscle and tendon pains by decoction. The previous studies reported that C. buchanani showed several pharmacological activities. In vitro study, the methanol crude extract of C. buchanani stem (12.5, 25, and 50 g/mL) showed the chondroprotective activity in cartilage degradation porcrine induced inflammation by interleukin-1 . In vivo study, the methanol crude extract of C. buchanani stem (60, 125, and 250 mg/kg) showed the analgesic activity against acetic acid-induced writhing response in mice and at the dose of 100, 250, and 500 mg/kg showed the anti-inflammatory activity on carrageenan-induced paw edema in rat. For the ethanol crude extract of stem (1, 5, 50, and 100 g/mL) showed the anti-inflammatory activity by inhibition of tumor necrosis factor-  production in lipopolysaccharide-stimulated human leukemia monocytic THP-1 cell. Moreover, the ethanol crude extract of C. buchanani leaves (250, and 500 mg/kg) showed the hepatoprotective activity in paracetamol-induced hepatotoxicity in rat. The aqueous crude extract of C. buchanani leaves showed the anti-bacterial activity against Klebsiella pneumonia with the minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) values are 1, and 2 g/L, respectively. Buchananine, an alkaloid which found in the stem, is the major active compound of C. buchanani. However, there are still no scientific evidences to support the pharmacological activities of the buchananine. Therefore, this review reports the pharmacological activities of C. buchanani for further intensive study, especially the effect of buchananine and other compounds from C. buchanani should be proved for their potentials to understand the mechanism of pharmacological actions of C. buchanani.

Article Details

Section
Review Article

References

Bureau of drug control: Food and drug administration Thailand. National list of essential medicines [online]. 2015 Sep 17 [cited 2016 May 20]. Available from: https://www.drug.fda.moph.go.th:81/nlem.in.th

Dutta SK, Sharma BN, Sharma PV. A new nicotinoyl glucoside from Cryptolepis buchanani. Phytochemistry 1980; 19: 1278.

Dutta SK, Sharma BN, Sharma PV. Buchananine, a novel pyridine alkaloid from Cryptolepis buchanani. Phytochemistry 1978; 17: 2047-2048.

Hanprasertpong N, Teekachunhatean S, Chaiwongsa R, et al. Analgesic, anti-inflammatory, and chondro protective activities of Cryptolepis buchanani extract: in vitro and in vivo studies. Biomed Res Int 2014; 2014: 1-8.

Kapol N, Tosanguan K, Thavornchareonsub M, Suksomboon N, Kunpeng W, Tantivess S, et al. Views of health professionals on herbal medicine and policy for promotion of herbal medicine use in health care settings. Nonthaburi: The Graphico systems company limited; 2011. (In Thai)

Kirtikar KR, Basu BD. Indian medicinal plants. Delhi: Taj press; 1981.

Laupattarakasem P, Wangsrimongkol T, Surarit R, Hahnvajanawong C. In vitro and in vivo anti-inflammatory potential of Cryptolepis buchanani. J Ethnopharmacol 2006; 108: 349-354.

Padmalochana K, Rajan MS, Lalitha R, Sivasankari H. Evaluation of the antioxidant and hepatoprotective activity of Cryptolepis buchanani. J App Pharm Sci 2013; 3(2): 99-104.

Purushothaman KK, Vasanth S, Comnolly JD, Rycroft DS. New sarverogenin and isosarverogenin in glycoside from Cryptolepis buchanani (Asclepiadaceae). J Mex Chem 1988; 19: 28-31.

Rao VR, Banning JW. Interactions of cryptosin with mammalian cardiac beta-adrenoceptors. Drug Chem Toxicol 1990; 13(2-3): 173-194.

Rueangrangsi N, Mangkhlakhup T. Thai herbal. Bangkok: Than printing; 2004. (In Thai)

Shah BB, Khare MP. Cryptolepis buchanani Roem.& Schult., a new source of sarmentogenin. J Nepal Chem Soc 1981; 1: 103-107.

Sittiwet C, Puangpronpitag D. Anti-bacterial of Cryptolepis buchanani Aqueous extract. Int J Biol Chem 2009; 3(2): 90-94.

Venkateswara R, Narenda N, Viswamitra MA, Vaidyanathan CS. Cryptosin-a new cardenolide in tissue culture and intact plants of Cryptolepis buchanani Roem.& Schult. Plant Cell Rep 1987; 6: 193-291.

Wu ZY, Raven PH, Deyuan H. Flora of china. Beijing: Science press; 1995.

Wuttidhammaved W. The Rattanakosin pharmacy ancient book. Bangkok: Odian store; 2007. (In Thai)