Vitamin D and type 2 diabetes mellitus

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รัชนีพร ชื่นสุวรรณ


The incidence of type 2 diabetes mellitus has been increasing worldwide. Vitamin D
deficiency, or the awareness of its prevalence, has also been increasing. Vitamin D is becoming
increasingly accepted as an important physiological regulator outside of its classical role in
skeletal homeostasis. Recent years have witnessed a significant scientific interest with vitamin
D, and these interests have expanded to include immune modulation, cell differentiation
and proliferation, and inflammation regulation. As our understanding of the many functions
of vitamin D has grown, the presence of vitamin D deficiency has become one of the most
prevalent micronutrient deficiencies worldwide. Vitamin D may have a role in predisposing the
pathogenic mechanisms to type 2 diabetes, by modulating insulin resistance and/or pancreatic
beta-cell function. In this review, we discuss up to date evidence linking vitamin D with the
development of diabetes, as well as the role of vitamin D supplementation in the prevention
of type 2 diabetes, and its function in improving glycemic control. We also address the potential
role of vitamin D deficiency in the development of macro- and microvascular complications
from diabetes. Finally, we provide a recommendation for vitamin D therapy in diabetic patients,
in view of current evidence, and highlight areas for potential future research in this topic.


Article Details

Review article


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