วงจรชีวิตของ Burkholderia pseudomallei Life Cycle of Burkholderia pseudomallei

Main Article Content

นราพร สมบูรณ์นะ Naraporn Somboonna สลิษา เบญจสกุลลือชา Salisa Benjaskulluecha

Abstract

Burkholderia pseudomallei is a causative bacterial pathogen of melioidosis, which is found highly in tropical region like the Northeast of Thailand and has a high mortality rate. The symptoms vary, causing the difficulty in the clinical diagnosis by the doctors. Besides, no effective antibiotic is available to date, because B. pseudomallei contains a variety of virulence factors, allowing the bacteria to reside inside and outside of the human host cell, and spread to different organs. These virulence factors include capsule, quorum sensing, type III secretion system and flagella, for examples. Moreover, B. pseudomallei has developed antibiotic resistant, and has been reportedly used as bioweapon. This review article, therefore, presented details on morphology, pathogenesis, human host cell intracellular and extracellular
developmental cycle, host cell entry mechanism, and antibiotic resistance mechanisms. Together, the knowledges assist in disease recognition, treatment strategy, and so on.

Article Details

Section
Review Article
Author Biographies

นราพร สมบูรณ์นะ Naraporn Somboonna, Department of Microbiology, Faculty of Science, Chulalongkorn University, Bangkok 10330

Department of Microbiology, Faculty of Science, Chulalongkorn University, Bangkok 10330

สลิษา เบญจสกุลลือชา Salisa Benjaskulluecha, Fourth Year Bachelor Student, Department of Microbiology, Faculty of Science, Chulalongkorn University Bangkok 10330

Fourth Year Bachelor Student, Department of Microbiology, Faculty of Science, Chulalongkorn University Bangkok 10330