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Curcumin, an active ingredient of turmeric, is known potent anti-inflammatory and anti-rheumatic properties. Rheumatoid arthritis (RA) is a chronic destructive joint disease. Many patients with severe forms of the disease remain unresponsive to non-steroidal anti-inflammatory drugs and disease modifying anti-rheumatic drugs (DMARDS) or DMARD-intolerance. This study conducts a randomized control study to assess the efficacy and safety of turmeric compare with placebo in Buddhachinaraj Hospital Phitsanulok. Fifty active rheumatoid arthritis patients who take maximum dose of DMARDS or DMARD-intolerance were randomized into two groups with patients receiving turmeric (2gm/d) and placebo for 8 weeks. The primary endpoints were reduction in Disease activity score (DAS) 28. The secondary endpoints were American College of Rheumatology (ACR) criteria for reduction in tenderness and swelling of joint counts. Patients in turmeric group showed statistically significant reduction in their DAS28 and ACR scores (ACR20, 50 and 70). Turmeric treatment did not related with any adverse events. This study provides the safety and efficacy of turmeric treatment in refractory RA, and highlights the need for future large-scale trials to validate these findings
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