Prevalence of Primary HIV-1 Drug Resistance Among Patients with HIV-1 Infection/AIDS in Bamrasnaradura Infectious Disease Institute
After a decade of scaling up of antiretroviral therapy in Thailand, the emergence of primary HIV-1 drug resistance (HIVDR) was demonstrated. In this study the authors analyzed the baseline HIV-1 genotyping assay of antiretroviral naive HIV-1 infected patients associated with tuberculosis (TB) enrolled to a randomized control trial of 4 weeks versus 12 weeks of antiretroviral therapy after TB treatment between October 2009 to May 2011. The purpose were to determine the prevalence of primary HIVDR among patients with HIV-1 infection/AIDS and factors related. Of 155 patients included in the study, 78.1% were male and mean (SD) age was 37.9 (8.7) years. Median (IQR) CD4 cell counts were 42 (17-107) cell/mm3. The prevalence of primary HIVDR was 3.9%. The prevalence of primary HIVDR to nucleoside analogue reverse transcriptase inhibitors, nonnucleoside reverse transcriptase inhibitors and protease inhibitors were 1.3%,1.9% and 0.6% respectively. Compared clinical characteristics between patients with and without primary HIVDR, there were no significant difference in age, sex, body weight, CD4 cell count, HIV-1 RNA level, mode of HIV-1 transmission and HIV-1 subtype (p>0.05). Regular surveillance of primary HIVDR in HIV infected patients in Thailand should be done.
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