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Alzheimer’s disease (AD) is a progressive neurodegenerative disease that showed impairment of learning and memory as well as cognitive function. It is cause of increased morbidity and mortality in elderly. Nowadays, nonpharmacological treatment has been great interest. Exercise has been considered as a treatment and prevention strategy for AD. Because exercise enhance brain blood flow, increase hippocampal volume, and improve neurogenesis. Several evidences indicated that physical activity are associated with a reduced risk of development of the disease. Exercise can improve cognitive function and slow down decline in activities of daily living (ADL). Moreover, exercise have fewer side effects when compared to medications.