In Vitro Release Study of Niacinamide and Caffeine from Different Creams
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Abstract
The present study was to formulate and study the release of niacinamide (vitamin B3) and caffeine from three different cream bases, vanishing cream, hydrophilic emulsion and cold cream. The releases of active components were evaluated using Franz-type diffusion cells with artificial membrane. Both vanishing cream and hydrophilic emulsion are the same in o/w type with difference in emulsifying agent and oil components. The vanishing cream is more liquid than hydrophilic emulsion where as the cold cream is w/o type with the most inflexible. In vitro releases of niacinamide and caffeine from three cream bases showed the similar kinetics. Both niacinamide and caffeine showed the highest release amounts and the fastest rates in vanishing cream. The lowest release amounts and release rates were found in cold cream. The results of the study suggest that the components and types of cream bases strongly affect the release of the actives from the formulations.
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