Attention-Deficit/Hyperactivity Disorder in Childhood Epilepsy in Ramathibodi Hospital and Related Factors

Main Article Content

ภัทรพร ปานดี
คมสันต์ เกียรติรุ่งฤทธิ์
สัญชัย กุลาดี
ชัยยศ คงคติธรรม
ภัทรพร วิสาจันทร์
สุดาวรรณ จุลเกตุ

Abstract

Objective : To study the prevalence of attention-deficit/ hyperactivity disorder (ADHD)
in pediatric patients with epilepsy and factors related to attention-deficit/ hyperactivity
symptoms and epilepsy at Ramathibodi hospital.
Methods : A cross-sectional descriptive study was conducted at epilepsy clinic,
Ramathibodi hospital. Parents of children with epilepsy were asked to answer the
demographic questionnaire and ADHD screening test (SNAP-IV). Seizure characteristics
were collected by medical record review.
Results : From the hundred patients (0.6:0.4, male: female), whose mean age was 10.21,
30 % (n=30) had attention-deficit/hyperactivity disorder. Of the latter group, 43.33 %
(n=13) were of combined-presentation. Comorbidity with autism spectrum disorders
(ASD) and younger paternal age were found to be associated factors of ADHD symptoms
in epilepsy patients, none of the epilepsy-related factors is significantly associated with
ADHD symptom.
Conclusion : The prevalence of attention-deficit/hyperactivity symptoms in patients at
Ramathibodi hospital with epilepsy is higher than the general population. However,
most of the risk factors are similar to the general patients with ADHD.

Article Details

How to Cite
ปานดี ภ., เกียรติรุ่งฤทธิ์ ค., กุลาดี ส., คงคติธรรม ช., วิสาจันทร์ ภ., & จุลเกตุ ส. (2019). Attention-Deficit/Hyperactivity Disorder in Childhood Epilepsy in Ramathibodi Hospital and Related Factors. Journal of the Psychiatric Association of Thailand, 64(1), 33–44. Retrieved from https://he01.tci-thaijo.org/index.php/JPAT/article/view/180509
Section
Original Articles

References

Davies S, Heyman I, Goodman R. A population survey of mental health problems in children with epilepsy. Dev Med Child Neurol 2003; 45: 292-5.

Berg AT, Caplan R, Hesdorffer DC. Psychiatric and neurodevelopmental disorders in childhood-onset epilepsy. Epilepsy Behav 2011; 20: 550-5.

Aaberg KM, Bakken IJ, Lossius MI, Lund Soraas C, Haberg SE, Stoltenberg C, et al. Comorbidity and Childhood Epilepsy: A Nationwide Registry Study. Pediatrics 2016; 138: e20160921.

Plioplys S, Dunn DW, Caplan R. 10-year research update review: psychiatric problems in children with epilepsy. J Am Acad Child Adolesc Psychiatry 2007; 46: 1389-402.

Cornaggia CM, Beghi M, Provenzi M, Beghi E. Correlation between cognition and behavior in epilepsy. Epilepsia 2006; 47: 34-9.

Jones JE, Watson R, Sheth R, Caplan R, Koehn M, Seidenberg M, et al. Psychiatric comorbidity in children with new onset epilepsy. Dev Med Child Neurol 2007; 49: 493-7.

Dunn DW, Austin JK, Perkins SM. Prevalence of psychopathology in childhood epilepsy: categorical and dimensional measures. Dev Med Child Neurol 2009; 51: 364-72.

Thome-Souza S, Kuczynski E, Assumpçao Jr F, Rzezak P, Fuentes D, Fiore L, et al. Which factors may play a pivotal role on determining the type of psychiatric disorder in children and adolescents with epilepsy? Epilepsy Behav 2004; 5: 988-94.

Devinsky O. Psychiatric comorbidity in patients with epilepsy: implications for diagnosis and treatment. Epilepsy Behav 2003; 4 Suppl 4: S2-10.

Guilherme Polanczyk MD, Maurício Silva de Lima MD, Ph.D. The Worldwide Prevalence of ADHD: A Systematic Review and Metaregression Analysis. Am J Psychiatry 2007: 164: 942-8.

Froehlich TE, Lanphear BP, Epstein JN, Barbaresi WJ, Katusic SK, Kahn RSJAop, et al. Prevalence, recognition, and treatment of attention-deficit/hyperactivity disorder in a national sample of US children. Arch Pediatr Adolesc Med 2007; 161: 857-64.

Faraone SV, Sergeant J, Gillberg C, Biederman JJWp. The worldwide prevalence of ADHD: is it an American condition? World psychiatry 2003; 2: 104.

Visanuyothin T, Pavasuthipaisit C, Wachiradilok P, Arunruang P, Buranasuksakul TJJoMHoT. The prevalence of attention deficit/hyperactivity disorder in Thailand 2013; 21: 66-75.

Reilly C, Atkinson P, Das KB, Chin RF, Aylett SE, Burch V, et al. Neurobehavioral comorbidities in children with active epilepsy: a population-based study. Pediatrics 2014; 133: e1586-93.

Bertelsen EN, Larsen JT, Petersen L, Christensen J, Dalsgaard S. Childhood Epilepsy, Febrile Seizures, and Subsequent Risk of ADHD. Pediatrics 2016; 138: e20154654.

Kang SH, Yum MS, Kim EH, Kim HW, Ko TS. Cognitive function in childhood epilepsy: importance of attention deficit hyperactivity disorder. J Clin Neurol 2015; 11: 20-5.

Tovia E, Goldberg-Stern H, Ben Zeev B, Heyman E, Watemberg N, Fattal-Valevski A, et al. The prevalence of atypical presentations and comorbidities of benign childhood epilepsy with centrotemporal spikes. Epilepsia 2011; 52: 1483-8.

Sherman EM, Slick DJ, Connolly MB, Eyrl KL. ADHD, neurological correlates and health-related quality of life in severe pediatric epilepsy. Epilepsia 2007; 48: 1083-91.

Williams AE, Giust JM, Kronenberger WG, Dunn DW. Epilepsy and attention-deficit hyperactivity disorder: links, risks, and challenges. Neuropsychiatr Dis Treat 2016; 12: 287-96.

Subchartanan J, Patharathitikul S, Chonchaiya WJAB. Prevalence of attention deficit hyperactivity disorder in children with epilepsy in a Thai Hospital. Asian Biomed 2015; 9: 803-7.

Reference incomplete. Biostatistics. 1995.

Swanson JM. School-based assessments and interventions for ADD students: KC publishing; 1992.

Pityaratstian N BT, Juengsiragulwit D, Benyakorn S. ADHD Screening Properties of the Thai Version of Swanson, Nolan,Pelham IV Scale (SNAP-IV) and Strengths and Difficulties Questionnaire (SDQ). Journal of the Psychiatric Association of Thailand. 2014; Vol. 59 No. 2.

Hermann B, Jones J, Dabbs K, Allen CA, Sheth R, Fine J, et al. The frequency, complications and aetiology of ADHD in new onset paediatric epilepsy. Brain 2007; 130: 3135-48.

Kaufmann R, Goldberg-Stern H, Shuper A. Attention-deficit disorders and epilepsy in childhood: incidence, causative relations and treatment possibilities. J Child Neurol 2009; 24: 727-33.

Dunn DW, Austin JK, Harezlak J, Ambrosius WT. ADHD and epilepsy in childhood. Dev Med Child Neurol 2003; 45: 50-4.

Hesdorffer DC, Ludvigsson P, Olafsson E, Gudmundsson G, Kjartansson O, Hauser WA. ADHD as a risk factor for incident unprovoked seizures and epilepsy in children. Arch Gen Psychiatry 2004; 61: 731-6.

Gonzalez-Heydrich J, Dodds A, Whitney J, MacMillan C, Waber D, Faraone SV, et al. Psychiatric disorders and behavioral characteristics of pediatric patients with both epilepsy and attention-deficit hyperactivity disorder. Epilepsy Behav 2007; 10: 384-8.

Dunn DW, Austin JK. Differential diagnosis and treatment of psychiatric disorders in children and adolescents with epilepsy. Epilepsy Behav 2004; 5 Suppl 3: S10-7.

Panyayong B. Psychiatric disorders of school-aged children in Bangkok Epidemiologic study. 1998.

Thapar A, Cooper M, Eyre O, Langley KJ. Practitioner review: what have we learnt about the causes of ADHD? J Child Psychol Psychiatry 2013; 54: 3-16.

Mayes SD, Calhoun SL, Crowell EWJ. Learning disabilities and ADHD: Overlapping spectrum disorders. J Learn Disabil 2000; 33: 417-24.

Christakou A, Murphy C, Chantiluke K, Cubillo A, Smith A, Giampietro V, et al. Disorder-specific functional abnormalities during sustained attention in youth with attention deficit hyperactivity disorder (ADHD) and with autism. Mol psychiatry 2013; 18: 236.

Berl MM, Terwilliger V, Scheller A, Sepeta L, Walkowiak J, Gaillard WD. Speed and complexity characterize attention problems in children with localization-related epilepsy. Epilepsia 2015; 56: 833-40.