TY - JOUR AU - Aniwattanapong, Daruj PY - 2018/12/26 Y2 - 2024/03/28 TI - Post-Stroke Depression JF - Journal of the Psychiatric Association of Thailand JA - J Psychiatr Assoc Thailand VL - 63 IS - 4 SE - Review Articles DO - UR - https://he01.tci-thaijo.org/index.php/JPAT/article/view/162961 SP - 383-418 AB - <p>Objective : To review evidence of post-stroke depression (PSD) for symptoms,<br>diagnosis, differential diagnosis, epidemiology, course, risk factors, pathophysiology,<br>screening tools, treatment and prevention including both pharmacological and<br>non-pharmacological interventions.<br>Method : MEDLINE/Pubmed, EMBASE, Cochrane Central Register of Controlled Trials<br>and other medical databases were searched for articles published between 1923-2018,<br>written in English, Thai and other languages, using factors related to post-stroke<br>depression, depression, depressive disorder, stroke and cerebrovascular disease as<br>keywords.<br>Result : Depression is the most common neuropsychiatric consequence of stroke.<br>It affects treatment and rehabilitation for stroke, impairs functional outcome and<br>increases mortality rate. Diagnosis of PSD was frequently overlooked because of<br>complex clinical manifestation. Currently, there is variance between epidemiological<br>factors in each study as a result of various assessment tools and the setting in which<br>patients were examined. Pathophysiology and risk factors of PSD are determined by both<br>biological and psychosocial factors, for instance, genetics and social factor. Evidence<br>has supported the benefits of the pharmacotherapy and psychosocial intervention for<br>PSD treatment and prevention.<br>Conclusion : Currently, there has been an increasing evidence of PSD. Early<br>diagnosis should be done by clinical assessment and appropriate screening tools.<br>Both pharmacotherapy and non-pharmacological interventions have efficacy for PSD<br>treatment and prevention. However, further research is needed to improve the quality<br>of evidence.</p> ER -