Main Article Content
Prasaplai is a Thai traditional herbal medicine in the National List of Essential Herbal Medicines used for the treatment of abnormal menstruation. However, there is no current clinical evidence to support the efficacy of Prasaplai on this indication. The aim of this study was to monitor the effects of Prasaplai on abnormal menstruation treatment in women who bought Prasaplai at Mahasarakham University drug store in order to treat their symptoms. The data were collected using questionnaires to evaluate clinical signs and symptoms before and after Prasaplai use for 1 week, 4 weeks (the 1st menstrual cycles), and 9 weeks (the 2nd menstrual cycles) in 24 women aged between 23.9 ± 1.3 years old. All of the subjects took 1-2 Prasaplai capsules (Prasaplai extract 250 mg/capsule) 3 times a day before meals. 70% of the subjects (17 individuals) suffered from oligomenorrhea. After Prasaplai administration, abnormal menstruation was cured in 7 persons and increased to 12 persons in the 1st and the 2nd menstrual cycles, respectively. There was no evidence of adverse drug reactions to Prasaplai. In conclusion, this study indicated that Prasaplai may be an effective and safe for treatment of abnormal menstruation. However, randomized controlled trials should be further performed to confirm the efficacy and safety of Prasaplai for this indication.
2. Heinemann LA, Minh TD, Heinemann K, Lindemann M, Filonenko A. Intercountry assessment of the impact of severe premenstrual disorders on work and daily activities. Health Care for Women International. 2012;33(2):109-24.
3. Rowland AS, Baird DD, Long S, Wegienka G, Harlow SD, Alavanja M, Sandler DP. Influence of medical conditions and lifestyle factors on the menstrual cycle. Epidemiology. 2002;13(6):668–74.
4. Matteson KA, Raker CA, Clark MA, Frick KD. Abnormal uterine bleeding, health status, and usual source of medical care: analyses using the Medical Expenditures Panel Survey. J Womens Health (Larchmt). 2013;22(11):959-65.
5. Bureau of drug control. Production cost and import medication into Thailand 1997-2008. [Internet]. 2008 [cited 2014 Jan 15]; Available from: http://wwwpp1.fda.moph.go.th./drug/zone_search/file/sea001_001.asp. (in Thai)
6. National List of Essential Medicines B.E. 2558 (2015). Thailand B.E. 2558 (2015), Government Gazette, Vol. 132, Part 184 ngor. (10 Aug 2015). (in Thai)
7. Boongen M. Study on Formulation and Stability Test of Prasaplai Extract Tablets and Capsules for dysmennorhea (thesis). Medical Sciences, Faculty of Medicine. Bangkok: Thammasat University; 2011. (116 p.). (in Thai)
8. Nualkaew S. Phytochemical and pharmacological studies of a Thai traditional preparation: Prasaplai (thesis). Pharmaceutical Chemistry and Pharmaceutical Phytochemistry, Faculty of Pharmacy. Bangkok: Mahidol University; 2004. (in Thai)
9. Kamalashiran C, Lekskulchai O. The comparative study of the efficacy and side effect of Prasaplai extract versus Mefenamic acid on relieving primary dysmenorrhea: A clinical phase II trials. Thammasat Medical Journal. 2012;12(4):749-56. (in Thai)
10. Sasum S. The development of Prasaplai capsule extract and efficacy for relieving primary dysmenorrhea (dissertation). Mahasarakham: Mahasarakham University; 2010. (in Thai)
11. Vannabhum M, Poopong S, Wongwananuruk T, Nimmannit A, Suwannatrai U, Dangrat C, Apichartvorakit A, Booranasubkajorn S, Laohapand T, Akaraserenont P. The Efficacy of Thai Herbal Prasaplai Formula for Treatment of Primary Dysmenorrhea: A Short-Term Randomized Controlled Trial. Evid Based Complement Alternat Med. 2016;2016:2096797.
12. Cohen J. A power primer. Psychological Bulletin. 1992;112(1):155-9.
13. Hofmeister S, Bodden S. Premenstrual syndrome and premenstrual dysphoric disorder. Am Fam Physician. 2016;94(3):236-40.
14. Tangchai K, Titapant V, Boriboonhirunsarn D. Dysmenorrhea in Thai adolescents: prevalence, impact and knowledge of treatment. J Med Assoc Thai. 2004;87 Suppl3:S69-73.
15. Ittharat A, et al. The report of efficacy and safety of Prasaplai for using in obstetrics and gynecology. Bangkok: Thammasat University; 2009. (in Thai)
16. Nualkaew S, Tiangda C, Gritsanapan W. Inhibitory action on rat uterine muscle contraction in vitro and acute toxicity in rats of the Thai traditional preparation Prasaplai. Nat Prod Res. 2013;27(4-5):491-5.
17. Waltenberger B, Schuster D, Paramapojn S, Gritsanapan W, Wolber G, Rollinger JM, Stuppner H. Predicting cyclooxygenase inhibition by three-dimensional pharmacophoric profiling. Part II: Identification of enzyme inhibitors from Prasaplai, a Thai traditional medicine. Phytomedicine. 2011;18(2-3):119-33.