Sensitivity and Specificity of Fine Needle Aspiration Cytology in Solid Neck Mass

Main Article Content

Banlue Uranakan


Background: Fine needle aspiration cytology is a valuable technique in the work-up of masses arising within neck and represents a screening, inexpensive, minimal invasive and rapid technique to sample masses found in neck at otolaryngology department in Buriram hospital.
Objective: To determine the sensitivity and specificity of fine needle aspiration cytology in diagnosis of solid neck mass by comparing the final pathological diagnosis with the initial FNAC.
Material & Methods: A retrospective study was conducted by reviewing the medical records of patients with thyroid and salivary gland tumors who underwent pre-operative FNAC and thyroidectomy at division of Otorhinolaryngology between 1st. January 2011 to 31th. December 2015.
Results: The total of 468 patients were included. FNAC was correlated with histology and the sensitivity, specificity, accuracy in diagnosis of neck mass, positive predictive value and negative predictive value were calculated. The overall results showed a sensitivity of 39.2%, specificity of 99.2%, diagnostic accuracy of 89.2%, positive predictive value of 90.6% and negative predictive value of 89.7% respectively.
Conclusion: FNAC for solid neck mass had high specificity and high diagnostic accuracy in diagnosis of thyroid and salivary gland tumors.
Keyword: FNAC ; Fine Needle Aspiration Cytology, Solid neck mass


Article Details

Original Articles


1. Gharib H, Dean DS.Fine-needle aspiration biopsy of the thyroid gland. Endotext [Internet].; [cited 2015 April 26]; [Retrived Nov 23, 2017.]; Available from:URL:

2. American Thyroid Association (ATA) Guidelines Taskforce on Thyroid Nodules and Differentiated Thyroid Cancer, Cooper DS, Doherty GM, Haugen BR, Kloos RT, Lee SL, et al. Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid 2009;19(11):1167-214.

3. Adhikari RC, Shrestha HK, Sharma SK. Fine needle aspiration cytology of neck masses in a hospital. J Nepal Health Res Counc 2014;12(27):104-8.

4. Shekhar H, Kaur A, Agrawal P, Pancharia A, Jadeja P. Fine needle aspiration cytology in head and neck swellings: a diagnostic and therapeutic procedure. Int J Res Med Sci 2014;2(4):1667-71.

5. Gharib H, Goellner JR. Fine-needle aspiration biopsy of the thyroid: an appraisal. Ann Intern Med 1993;118(4):282-9.

6. Schmidt RL, Hall BJ, Wilson AR, Layfield LJ. A systematic review and meta-analysis of the diagnostic accuracy of fine-needle aspiration cytology for parotid gland lesions. Am J Clin Pathol 2011;136(1):45-59.

7. Nguansangiam S, Jesdapatarakul S, Dhanarak N, Sosrisakorn K. Accuracy of fine needle aspiration cytology of salivary gland lesions: routine diagnostic experience in Bangkok, Thailand. Asian Pac J Cancer Prev 2012;13(4):1583-8.

8. Bini F, Janhvi JB, Hiran KR. Reliability of fine needle aspiration cytology in salivary nepplasms: surgeon’s perspective. Amrita Journal of Medicine 2014;10(2):23-9.

9. ปนัดดา ช่วยแก้ว. ค่าการทำนายโรคของการเจาะดูดก้อนของต่อมไทรอยด์ด้วยเข็มขนาดเล็กในโรงพยาบาลศรีนครินทร์. (อินเตอร์เน็ท).; 2562. [สืบค้น 15 มค.2562]. เข้าถึงได้จาก:URL:

10. Bajaj Y, De M, Thompson A. Fine needle aspiration cytology in diagnosis and management of thyroid disease. J Laryngol Otol 2006;120(6):467-9.

11. Morgan JL, Serpell JW, Cheng MS. Fine-needle aspiration cytology of thyroid nodules: how useful is it? ANZ J Surg 2003;73(7):480-3.

12. Sidawy MK, Del Vecchio DM, Knoll SM. Fine-needle aspiration of thyroid nodules: correlation between cytology and histology and evaluation of discrepant cases. Cancer 1997;81(4):253-9.

13. Nopkunwijai A. Fine needle aspiration cytology (FNAC) of thyroid nodule in Ratchaburi hospital. Reg 4-5 Med J 2006;25(2):211-7.

14. Kim N, Lavertu P. Evaluation of a thyroid nodule. Otolaryngol Clin North Am 2003;36(1):17-33.

15. Schiro AJ, Pinchot SN, Chen H, Sippel RS. Clinical efficacy of fine-needle aspiration biopsy of thyroid nodules in males. J Surg Res 2010;159(2):645-50.

16. Mahar SA, Husain A, Islam N. Fine needle aspiration cytology of thyroid nodule: diagnostic accuracy and pitfalls. J Ayub Med Coll Abbotta bad 2006;18(4):26-9.

17. Kessler A, Gavriel H, Zahav S, Vaiman M, Shlamkovitch N, Segal S, et al. Accuracy and consistency of fine-needle aspiration biopsy in the diagnosis and management of solitary thyroid nodules. Isr Med Assoc J 2005;7(6):371-3.

18. FrasoldatiA, Pesenti M, Gallo M, Caroggio A, Salvo D, Valcavi R. Diagnosis of neck recurrences in patients with differentiated thyroid carcinoma. Cancer 2003;97(1):90-6.

19. Seethala RR, LiVolsi VA, Baloch ZW. Relative accuracy of fine-needle aspiration and frozen section in the diagnosis of lesions of the parotid gland. Head Neck 2005;27(3):217-23.

20. Fundakowski C, Castaño J, Abouyared M, Lo K, Rivera A, Ojo R, et al. The role of indeterminate fine-needle biopsy in the diagnosis of parotid malignancy. Laryngoscope 2014;124(3):678-81

21. สมบูรณ์ คีลาวัฒน์. ปัญหาและทางแก้ของการให้การวินิจฉัยโรคในงานบริการของ fine-needle aspiration cytology. Chula Med J 2001;45(4): 275-82.