Different Histologic Types and Pretreatment Factors Associated with Anemia in Non-small Cell Lung Cancer Patients

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Benyapatch Eiamthanasinchai


Background: Anemia is common problem in lung cancer which impaired the effectiveness of treatment and quality of life. Lung cancer is divided into several types according to the histology. This study aimed to identified which histologic types of non-small cell lung cancer and factors associated with anemia in pretreatment lung cancer patients. The assessment may help in optimizing the care of anemic patients with lung cancer.
Objective: To determine the histologic types of lung cancer and factors associated with anemia in pretreatment non-small cell lung cancer patients.
Study design: Retrospective case-control study.
Methods: Non-small cell lung cancer patients in Surin hospital with histologically confirmed that were reviewed between January 1st, 2014 and June 30th, 2018 from electronic databases. Histologic types of lung cancer, clinical characteristics and laboratory tests were collected in all patients.
Results: One hundred and eighty four non-small cell lung cancer patients in Surin hospital were recruited and classified into 2 groups: anemia and non-anemia group equally. The histologic types of lung cancer were adenocarcinoma, squamous cell carcinoma, large cell carcinoma and others were significantly differences between anemia and non-anemia groups (p=0.011). Squamous cell carcinoma was association with anemia group more than other types(p=0.004) and adenocarcinoma was association with non-anemia group(p=0.003). Factors that significantly associated with anemia in non-small cell lung cancer were albumin <3.5 g/dl (OR=3.64, 95% CI: 0.14-0.45, p<0.001) and WBC <5000 cells/uL (OR=6.93, 95% CI: 0.01-0.67, p=0.047).
Conclusion: Histologic types of non-small cell lung cancer were significantly differences between anemia and non-anemia groups. Squamous cell carcinoma was massociated with anemia. The factors associated with anemia were albumin<3.5 g/dl and WBC <5000 cells/uL. These factors can be resolved for optimize the treatment, reduced complications from blood transfusion or used erythropoietin and improved quality of life.
Keywords: anemia, non-small cell lung cancer, pretreatment


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Original Articles


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