The Effect of Oropharyngeal Colostrum Administration on Immunoglobulin A in Preterm Infants

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Kritsadaporn Lobbamrung Tipawan Daramas Jariya Wittayasooporn

Abstract

Abstract:


         The present study was a quasi-experimental reseach to investigate the effect of oropharyngeal administration of colostrum on the levels of immunoglobulin A in preterm infants with gestational age less than 32 weeks, who were admitted into neonatal ward at Queen Sirikit National Institute of Child Health. The 10 preterm infants were recruited based on the inclusion criteria. The preterm infants received oral administration 0.2 ml of colostrum every three hours for 7 consecutive days. The oral administration began within 48 hours after birth. The secretory immunoglobulin A (sIgA) in urine was measured before oropharyngeal administration of colostrum within 24 hours after birth and after oropharyngeal administration of colostrum on the 5 th and 14th days after birth. Difference in the average of sIgA in urine was determined with the one-way repeated measure ANOVA. The result showed that the average level of sIgA in urine of the preterm infants before oropharyngeal administration of colostrum within 24 hours after birht was 117.47 ng/mL and after oropharyngeal admonistration of colostrum on the 5th and 14th days after birth was 101.97 ng/mL and 809.96 ng/mL, However, the average of sIgA in urine of pretern infants before and after oropharyngeal administration of colostrum were no statistical significant difference (p < .05). Limitation of this study used a small sample group, it is recommended that more research using a bigger sample shoud be done to better understand the relationship of the levels of sIgA in preterm infants, receiving oropharyngeal administrion of colostrum, providing care to preterm infants.

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How to Cite
1.
Lobbamrung K, Daramas T, Wittayasooporn J. The Effect of Oropharyngeal Colostrum Administration on Immunoglobulin A in Preterm Infants. Ramathibodi Nursing Journal [Internet]. 17Apr.2019 [cited 20Jun.2019];25(1):16-8. Available from: https://www.tci-thaijo.org/index.php/RNJ/article/view/122435
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บทความวิจัย

References

1. World Health Organization. Preterm birth; 2015 (cited 2015 April 16). Available from: https://who.int/mediacentre/factsheets/fs363/en/

2. March of Dimes. Annual report. 2015. (cited 2015 January 20). Available from: https://www.marchofdimes.org/materials/2015-annual-report.pdf

3. Blencowe H, Cousens S, Chou D, Oestergaard M, Say L, Moller A-B, et al. Born Too Soon: The global epidemiology of 15 million preterm births. Reprod Health. 2013;10 (2):1-14.

4. Gilbert WM, Nesbitt TS, Danielsen B. The cost of prematurity: quantification by gestational age and birth weight. Obstet Gynecol. 2003;102:488-92.

5. Johnson TJ, Patel AL, Jegier BJ, Engstrom JL, Meier PP. Cost of morbidities in very low birth weight infants. J Pediatr. 2013;162(2):243-49.

6. Maggie MD, Maggie H. Nursing the neonate. 2, editor. United Kingdom: John Wiley & Sons Ltd; 2011.

7. Borghesi A, Stronati M. Strategies for the prevention of hospital-acquired infections in the neonatal intensive care unit. J Hosp Infect. 2008;68(4):293-300.

8. Capasso L, Borrelli AC, Cerullo J, Pisanti R, Figliuolo C, Izzo F, et al. Role of immunoglobulins in neonatal sepsis. J Transl Med. 2015;11(5):28-33.

9. Adams CI. Long-term impact of infection on the preterm neonate. Semin Perinatol. 2012;36(6):462-70.

10. Lawrence RM, Pane CA. Human breast milk: current concepts of immunology and infectious diseases. Curr Probl Pediatr Adolesc Health Care. 2007;37(1):7-36.

11. Alison BR. Infection in the term and preterm infant. In: Helen Y, editor. Nursing the neonate. 2nd ed. United Kingdom: A John Wiley & Sons, Ltd., Publication; 2010. p. 274-93.

12. Clark R, Powers R, White R, Bloom B, Sanchez P, Benjamin DK, et al. Nosocomial infection in the NICU: a medical complication or unavoidable problem? J Perinatol. 2004;24(6):382-8.

13. Blewett H, Cicalo M, Holland C, Field C. The immunological components of human milk. Adv Food Nutr 2008;54:45-80.

14. Le Huërou-Luron I, Blat S, Boudry G. Breast- v. formula-feeding: impacts on the digestive tract and immediate and long-term health effects. Nutr Res Rev. 2010;23:23-36.

15. Araújo ED, Gonçalves AK, Cornetta MdC, Cunha H, Cardoso ML, Morais SS, et al. Evaluation of the Secretory Immunoglobulin A Levels in the Colostrum and Milk.pdf. BJID 2005;9(5):357-62.

16. Lee J, Kim HS, Jung YH, Choi KY, Shin SH, Kim EK, et al. Oropharyngeal colostrum administration in extremely premature infants: an RCT. Pediatrics. 2015;135(2): e357-66.

17. Rodriguez AN. Colostrum as a Therapeutic for Premature Infants. J Nutr Health. 2013;1:145-55.

18. Rodriguez AN, Meier PP, Groer MW, Zeller JM. Oropharyngeal administration of colostrumto extremely low birth weight infants: theoretical perspectives. J Perinatol. 2009;29(1):1-7.

19. Thibeau S, D’Apolito K. Review of the relationships between maternal characteristics and preterm breastmilk immune components. Biol Res Nurs. 2012;14(2):207-16.

20. Rodriguez AN, Groer WM, Zeller MJ, Engstrom LJ, Fogg Lou., Du H, et al. A Randomized Controlled Trial of the Oropharyngeal Administration of Mother’s Colostrum to Extremely Low Birth Weight Infants in the First Days of Life. Neonatal Intensive Care. 2011;24(4):30-5.

21. Rodriguez AN, Caplan MS. Oropharyngeal administration of mother’s milk to prevent necrotizing enterocolitis in extremely low-birth-weight infants: theoretical perspectives. J Perinat Neonatal Nurs. 2015;29(1):81-90.

22. Seigel JK, Smith PB, Ashley PL, Cotton CM, Herbert CC, King BA. Early administration of oropharyngeal colostrum to extremely low birth weight infants. Breastfeed Med. 2013; 8(6):491 -5.

23. Caprio M, Barr PA, Kim Y, Cruz H. Effects of establishing a feeding protocol to improve nutrition in premature neonates. Paper presented at Pediatric Academic Societies. 2013.

24. Gephart SM, Weller M. Colostrum as oral immune therapy to promote neonatal health. Advances in neonatal care : Adv Neonatal Care. 2014;14(1):44-51.

25. Andersson B, Porras O, Hanson LA, Lagergard T, Svanborg-Eden C. Inhibition of attachment of streptococcus pneumoniae and haemophilus influenzae by human milk and receptor oligosaccharides. Infect Disease. 1986;153:232-7.

26. Newburg DS, Walker WA. Protection of the neonate by the innate immune system of developing gut and of human milk. Pediatr Res. 2007;95:1075-81.

27. Koldovsky O. The potential physiologic significance of milk-borne hormonally active substances for the neonate. J Mammary Gland Biol Neoplasia 1996;1:317-23.

28. Bocci V. The oropharyngeal delivery of interferons: where are we and where do we need to go? J Interferon Cytokine Res. 1999;19:859-61.

29. Garofalo R. Cytokines in human milk. J Pediatr. 2010;156:36-40.

30. Rodriguez NA, Meier PP, Groer MW, Zeller JM, Engstrom JL, Fog5857g L. A pilot study to determine the safety and feasibility of oropharyngeal administration of own mother’s colostrum to extremely low-birth-weight infants. Adv Neonatal Care. 2010;10(4):206-12.

31. Faul F, Erdfelder E, Buchner A, Lang A-G. Statistical power 3.1: tests for correlation and regression analyses. Behavior Research Methods. 2009; 41(4):1149-60.

32. Kawano A, & Emori, Y. Changes in maternal secretory immunoglobulin a levels in human milk during 12 weeks after parturition. Am J Hum Biol. 2013;25(3): 399-403.

33. Lepage P, & Van de Perre, P. The immune system of breast milk: antimicrobial and anti-inflammatory properties. Adv Exp Med Biol. 2012;743: 121-37.

34. Araújo ED, Conceição, M., Cornetta H. C., Maria, L. Cardoso, S. M., and Giraldo, P. C. . Evaluation of the Secretory Immunoglobulin A Levels in the Colostrum and Milk of Mothers of Term and Pre-Term Newborns. BJID. 2005;9:357-62.

35. Castellote C, Casillas R, Ramirez-Santana C, Perez-Cano, FJ., Castell M, Moretones MG, et al. Premature delivery influences the immunological composition of colostrum and transitional and mature human milk. J Nutrit. 2011;141(6): 1181-7.

36. Zhang Y, Ji F, Hu X, Cao Y, Latour JM. Oropharyngeal Colostrum Administration in Very Low Birth Weight Infants: A Randomized Controlled Trial. Pediatr Crit Care Med. 2017;18(9):869-75.