Diagnostic role of urine C-reactive protein levels on ureteral stone disease

Authors

  • Ozer Guzel University of Health Sciences, Ankara Numune Research and Training Hospital, Department of Urology, Sihhiye, Ankara, Turkey
  • Yilmaz Aslan University of Health Sciences, Ankara Numune Research and Training Hospital, Department of Urology, Sihhiye, Ankara, Turkey
  • Altug Tuncel University of Health Sciences, Ankara Numune Research and Training Hospital, Department of Urology, Sihhiye, Ankara, Turkey
  • Cagdas Senel University of Health Sciences, Ankara Numune Research and Training Hospital, Department of Urology, Sihhiye, Ankara, Turkey
  • Ahmet Asfuroglu University of Health Sciences, Ankara Numune Research and Training Hospital, Department of Urology, Sihhiye, Ankara, Turkey
  • Esra Firat Oguz University of Health Sciences, Ankara Numune Research and Training Hospital, Department of Medical Biochemistry, Sihhiye, Ankara, Turkey
  • Fatma Meric Yilmaz University of Health Sciences, Ankara Numune Research and Training Hospital, Department of Medical Biochemistry, Sihhiye, Ankara, Turkey
  • Melih Balci University of Health Sciences, Ankara Numune Research and Training Hospital, Department of Urology

Keywords:

ureter, stone disease, diagnosis, urine C-reactive protein level

Abstract

Objective: To investigate the importance of serum and urine CRP levels in patients with ureteral stone.

Material and Method: Seventy-six patients were included in this study. Forty-nine patients in Group 1 had ureteral stones while 27 healthy volunteers in Group 2 were included as controls. Demographic data, preoperative radiologic imaging and perioperative findings of the patients (including stone size, presence of stone impaction etc.) were recorded. Serum and urine CRP levels were measured on the morning of surgery. Urine CRP was measured by quantitive sandwich enzyme immunoassay technique with Immunodiagnostic brand ELISA kit (BensheimR,Germany).

Result: Twelve stones (24.5%) were found to be obstructive. The mean serum and urine CRP values of participants were; 12.1mg/l and 10.5ng/dl in Group 1, and 1.5mg/l and 6.1ng/dl in Group 2, respectively (pserumCRP=0.002, purineCRP=0.001). The serum and urine CRP levels were found to be 20.2mg/l and 12.8ng/dl for obstructive stones and 9.1mg/l and 9.8ng/dl for non-obstructive stones, respectively (pserum CRP =0.133) (purine CRP =0.492).  According to the ROC analysis, the best cut-off value of serum and urine CRP were 2.4mg/l and 6.7ng/dl respectively. The sensitivity, specificity values of the serum and urine CRP measurement were 78.0%, 85.2% and 63.5%, 85.1% respectively.

Conclusion: Serum and urine CRP measurement are candidate to be a new marker for ureteral stones. The usage of serum and urine CRP levels may support presence and impaction of ureteral stone. We believe further studies involving larger series are necessary before more definite conclusions can be drawn.

 

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Published

2018-12-05

How to Cite

Guzel, O., Aslan, Y., Tuncel, A., Senel, C., Asfuroglu, A., Oguz, E. F., Yilmaz, F. M., & Balci, M. (2018). Diagnostic role of urine C-reactive protein levels on ureteral stone disease. Insight Urology, 39(2), 35–41. Retrieved from https://he02.tci-thaijo.org/index.php/TJU/article/view/118795

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