Paraneoplastic syndrome of renal cell carcinoma in Phramongkutklao Hospital

Main Article Content

Saravut Mingarcha Sarayut Kanjanatarayon Nattapong Binsri Satit Siriboonrid


Introduction :

Incidental renal lesion is the most common cause that bring renal cell carcinoma (RCC) patients to urologist and almost of them are asymptomatic. The symptoms of them usually due to locally advanced diseases such hematuria, flank or abdominal pain, palpable mass and the unique presentation of RCC is paraneoplastic syndrome.

Objective :

To study the prevalence of paraneoplastic syndromes in patients with RCC and association between paraneoplastic syndromes and staging of RCC.

Material and Methods :

This retrospective study was analyzed 205 patients of RCC in Phramongkutklao hospital during 2007-2017. These data were consisted of paraneoplastic syndromes parameters and pathologic staging.

Results :

119 (58%) RCC patients were asymptomatic group and 86 (42%) RCC patients were symptomatic group. The prevalence of paraneoplastic syndromes were 24.4% (elevated ESR 16.6%, hypertension 13.2%, anemia 12.2%, weight loss 10.7%, pyrexia 9.3%, abnormal liver function 12.7%, hypercalcemia 2.9% and polycythemia 0.97%). Symptomatic patients had significantly more paraneoplastic syndromes (odd ratio=11.13) and higher stage(p<0.001).

Conclusion :

The prevalence of paraneoplastic syndrome was found 24.4% in patients with RCC, elevated ESR is the most common parameter.  Symptomatic patients had more paraneoplastic syndromes and higher stage of RCC.


Article Details

How to Cite
Mingarcha, S., Kanjanatarayon, S., Binsri, N., & Siriboonrid, S. (2019). Paraneoplastic syndrome of renal cell carcinoma in Phramongkutklao Hospital. The Thai Journal of Urology, 40(2), 56-60. Retrieved from
Original article


1. Moreira D. Paraneoplastic syndromes are associated with adverse prognosis among patients with renal cell carcinoma undergoing nephrectomy. J Urol 2015:193; e531. https://doi. org/10.1016/j.juro.2015.02.1556

2. Hyung L. Kim: Paraneoplastic signs and symptoms of renal cell carcinoma implications for prognosis. J Urol 2003;170:1742-6.

3. Yao-Chi Chuang. Paraneoplastic elevation of serum alkaline phosphatase in renal cell carcinoma incidence and implication on prognosis. J Urol 1997;158:1684-7.

4. gold PJ, Ferer A, Thompson JA. Paraneoplastic manifestations of renal cell carcinoma. Semin Urol Oncol 1996;14:216-22.

5. Klatte T, Said JW, Belldegrun AS, et al. Differential diagnosis of hypercalcemia in renal malignancy. Urology 2007;70:e7-8.

6. Hannisdal E. Erythrocyte sedimentation rate
as a prognostic factor in renal cell carcinoma. Eur J Surg Oncol (EJSO) 1989;15:333-6.

7. McClellan M. Hypercalcemia in patients with metastatic renal cell carcinoma: Effect of nephrectomy and metabolic evaluation. J Urol 1997;158;733-9.

8. Mohammad Mozayen. Prognostic significance of degree of anemia in renal cell carcinoma. J Clin Oncol (JCO) 30;5:469.

9. Kim HL, Belldegrun AS, Freitas DG, et al. Paraneoplastic signs and symptoms of renal cell carcinoma: implications for prognosis. J Urol 2003;170:1742.

10. Tsui KH, Shvarts O, Smith RB, et al. Renal cell carcinoma: prognostic significance of incidentally detected tumors. J Urol 2000;163:426.

11. Fuhrman SA, Lasky LC, Limas C. Prognostic significance of morphologic parameters in renal cell carcinoma. Am J Surg Pathol 1982:6;655-63.

12. Rosenblum SL. Paraneoplastic syndromes associated with renal cell carcinoma. J S C Med Assoc 1987;83:375.

Most read articles by the same author(s)