Factors associated with carbapenem -resistant Pseudomonas aeruginosa strain infections among patients of Roi Et Hospital, Thailand

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Nuntiput Putthanachote
Witoo Klabtawee
Narongchai Sangsa
Srikrit Pakmaruek
Wongklang Kudwongsa
Pongdech sarakarn

Abstract

Nosocomial infection caused by carbapenem-resistant Pseudomonas aeruginosa strains (CRPA) is a serious problem worldwide. Infected patients are difficult to treat, leading to high mortality rate especially septicemia. The objective of this study was to investigate the factors associated with CRPA infections among patients at Roi Et Hospital, Roi Et Province. Study design was a hospital based case-control study. All processes were conducted at Roi Et Hospital. The variables of interest were retrieved from medical records of patients who admitted during January 1, 2014 to December 31, 2015. The laboratory processes were followed the guidelines of the CLSI January, 2010. Data were analyzed using descriptive statistic, univariable analysis and multivariable analysis by multiple logistic regressions. Of which 85 cases, most of them were female (54.2%) with mean age was 62.5+16.2 years, couple status was 72.9 % and agriculture 63.5 %. Of 85 controls, most of them were male (55.3 %) with mean age of 57.9+ 18.3 years, couple status was 61.2 % and agriculture 43.5 %. The factors associated with CRPA infections were hospital stay more than 7 days (OR Adj. =2.6:95%CI; 1.32-4.87), tracheostomy (OR Adj. =2.0:95%CI; 1.07- 4.79), endotracheal tube (OR Adj. =2.7:95%CI; 1.31- 5.57) and mechanical ventilators (OR Adj. =3.1:95%CI; 1.42- 6.38). Antibiotic exposure included the third-generation cephalosporins (OR Adj. =2.1:95%CI; 1.10- 3.91), carbapenems (OR Adj. =2.9:95%CI; 1.34- 5.68) and glycopeptides (OR Adj. =3.3:95%CI; 1.95- 11.09). In conclusion, the hospitalization, tracheostomy, endotracheal tube, mechanical ventilators, the third-generation cephalosporins, carbapenems and glycopeptides were factors associated with CRPA infections.

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1.
Putthanachote N, Klabtawee W, Sangsa N, Pakmaruek S, Kudwongsa W, sarakarn P. Factors associated with carbapenem -resistant Pseudomonas aeruginosa strain infections among patients of Roi Et Hospital, Thailand. Arch AHS [Internet]. 2017 Jul. 18 [cited 2024 Mar. 28];29(1):34-43. Available from: https://he01.tci-thaijo.org/index.php/ams/article/view/93413
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