Bilateral Idiopathic Granulomatous Mastitis: A Case Report
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Sep 20, 2014
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Abstract
Idiopathic granulomatous mastitis is a rare, chronic inflammatory disease of the breast that frequently occurs in young women of childbearing age. The lesion usually presents as a unilateral firm breast mass with signs of inflammation but bilateral involvement has been reported. As the clinical presentation and radiological imaging of idiopathic granulomatous mastitis can mimic two common breast diseases, mastitis with abscess and breast cancer, a tissue biopsy is required for histopathological diagnosis. The etiology and ideal treatment remain unclear. Conservative treatment with immunosuppressive therapy has proven good efficacy. In this case report, we present a patient diagnosed with bilateral idiopathic granulomatous mastitis. We review and discuss the clinical presentation, imaging, diagnosis and management of this patient that eventually responds well to steroid therapy.
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1.
Likhitmaskul T, Sukpanich R, Visutdiphat S, Vassanasiri W. Bilateral Idiopathic Granulomatous Mastitis: A Case Report. BKK Med J [Internet]. 2014 Sep. 20 [cited 2024 Apr. 20];8(1):65. Available from: https://he02.tci-thaijo.org/index.php/bkkmedj/article/view/220082
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Case Report
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References
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2. Erhan Y, Veral A, Kara E, et al. A clinicopathologic study of a rare clinical entity mimicking breast carcinoma: idiopathic granulomatous mastitis. Breast 2000, 9:52-6.
3. Kessler E, Wolloch Y. Granulomatous mastitis: a lesion clinically simulating carcinoma. Am J Clin Pathol 1972; 58:642-6.
4. Akbulut S, Yilmaz D, Bakir S. Methotrexate in the man-agement of idiopathic granulomatous mastitis: review of 108 published cases and report of four cases. Breast J 2011;17:661-8.
5. Rubin G, Meerkotter DA. Idiopathic granulomatous mastitis. SA Journal of radiology 2011;15:4-5.
6. Boufettal H, Hermas S, Noun M, et al. Mastite granulo-mateuse idiopathique bilatérale. Imagerie Femme 2009; 19:262-4.
7. Baslaim MM, Khayat HA, Al-Amoudi SA. Idiopathic granulomatous mastitis: A heterogeneous disease with variable clinical presentation. World J Surg 2007;31:1677-81.
8. Lai EC, Chan WC, Ma TK, et al. The role of conservative treatment in idiopathic granulomatous mastitis. Breast J 2005;11:454-6.
9. Patel RA, Rodriguez M. Idiopathic granulomatous mastitis:case report and review of literature. J Gen Intern Med 2010;25:270-3.
10. Brown KL, Tang PH. Postlactational tumoral granulo-matous mastitis: A localized immune phenomenon. Am J Surg 1979;138:326-9.
11. Diesing D, Axt-Fliedner R, Hornung D, et al. Granulo-matous mastits: Review article. Arch Gynecol Obstet 2004;269:233-6.
12. Akcan A, Akyildiz H, Deneme MA, et al. Granulomatous lobular mastitis: A complex diagnostic and therapeutic problem. World J Surg 2006;30:1403-9.
13. Bani-Hani KE, Yaghan RJ, Matalka II, et al. Idiopathic granulomatous mastitis: time to avoid unnecessary mas- tectomies. Breast J 2004;4:318-22.
14. Akbulut S, Arikanoglu Z, Senol A, et al. Is methotrexate an acceptable treatment in the management of idiopathic granulomatous mastitis? Arch Gynecol Obstet 2011; 284:1189-95.
15. Kim J, Tymms KE, Buckingham JM. Methotrexate in the management of granulomatous mastitis. ANZ J Surg 2003;73:247-9.
16. Binesh F, Kargar S, Zahir ST, et al. Idiopathic granulo-matous mastitis, a clinicopathological review of 22 cases. J Clin Exp Pathol 2014;4:157.
17. Lin CH, Hsu CW, Tsao TY, et al. Idiopathic granulomatous mastitis associated with risperidone-induced hyperpro-lactinemia. Diagn Pathol 2012 ;7:2.
18. Fletcher A, Magrath IM, Riddell RH, et al. Granulomatous mastitis: a report of seven cases. J Clin Pathol 1982;35:941-5.
19. Imoto S, Kitaya T, Kodama T, et al. Idiopathic granulo-matous mastitis: case report and review of the literature. Jpn J Clin Oncol 1997;27:274-7.
20. Garcia-Rodiguez JA, Pattullo A. Idiopathic granuloma-tous mastitis: a mimicking disease in a pregnant woman: a case report. BMC Res Notes 2013;6:95.
21. Olsen ML, Dilaveri CA. Idiopathic granulomatous mastitis: a case report of breast abscess. BMJ Case Rep 2011: pii: bcr0520114271. doi: 10.1136/bcr.05.2011.4271.
22. Azlina AF, Ariza Z, Arni T, et al. Chronic granulomatous mastitis: diagnostic and therapeutic considerations. World J Surg 2003;27:515-8.
23. Reddy KM, Meyer CE, Nakdjevani A, et al. Idiopathic granulomatous mastitis in the male breast. Breast J 2005; 11:73.
24. Goldberg J, Baute L, Storey L, et al. Granulomatous mastitis in pregnancy. Obstet Gynecol 2000;96:813-5.
25. Erozgen F, Ersoy YE, Akaydin M, et al. Corticosteroid treatment and timing of surgery in idiopathic granuloma- tous mastitis confusing with breast carcinoma. Breast Cancer Res treat 2010;123:447-52.
26. Han B, Choe YH, Park JM, et al. Granulomatous mastitis mammographic and sonographic appearances. AJR 1999; 173:317-20.
27. Veyssiere C, Vives M, Smadia A. Difficultés diagnostiques de la tuberculose mammaire. Le problème de la mastite granulomateuse. Lille Chir 1967;22:104-9.
28. Raj N, Macmillan RD, Ellis IO, et al. Rheumatologists and breasts: immunosuppressive therapy for granulomatous mastitis. Rheumatology (Oxford) 2004;43:1055-6.
29. Cserni G, Szajki K: Granulomatous lobular mastitis following drug-induced galactorrhoea and blunt trauma. Breast J 1999;5:398-403.
30. Rowe PM. Granulomatous mastitis associated with a pituitary prolactinoma. Br J Clin Pract 1984;38:32-4.
31. Lee JH, Oh KK, Kim EK, et al. Radiologic and clinical features of idiopathic granulomatous lobular mastitis mimicking advanced breast cancer. Yonsei Med J 2006; 47:78-84.
32. Al-Khaffaf B, Knox F, Bundred NJ. Idiopathic granu-lomatous mastitis: a 25-year experience. Amer Col Surg 2008; 206:269-72.
33. Taylor GB, Paviour SD, Musaad S, et al. A clinicopatho-logical review of 34 cases of inflammatory breast disease showing an association between corynebacteria infection and granulomatous mastitis. Pathology 2003;35:109-19.
34. Wilson JP, Massoll N, Marshall J, et al. Idiopathic granu-lomatous mastitis: In search of a therapeutic paradigm. Am Surg 2007;73:798-802.
35. Pandey TS, Mackinnon JC, Bressler L, et al. Idiopathic granulomatous mastitis−a prospective study of 49 women and treatment outcomes with steroid therapy. Breast J 2014;20:258-66.
36. Ayeva-Derman M, Perrotin F, Lefrancq T, et al. Idiopathic granulomatous mastitis. Review of the literature illustrated by 4 cases. J Gynecol Obstet Biol Reprod (Paris) 1999;28:800-7.
37. Vingerhoedt NM, Janssen S, Mravunac M, et al. Granu- lomatous lobular mastitis: A benign abnormality that mimics malignancy. Ned Tijdschr Geneeskd 2008;152:1052-6.
38. Asoglu O, Ozmen V, Karanlik H, et al. Feasibility of surgical management in patients with granulomatous mastitis. Breast J 2005;11:108-14.
39. Gurleyik G, Aktekin A, Aker F, et al. Medical and surgical treatment of idiopathic granulomatous lobular mastitis: A benign inflammatory disease mimicking invasive carcinoma. J Breast Cancer 2012;15:119-23.
2. Erhan Y, Veral A, Kara E, et al. A clinicopathologic study of a rare clinical entity mimicking breast carcinoma: idiopathic granulomatous mastitis. Breast 2000, 9:52-6.
3. Kessler E, Wolloch Y. Granulomatous mastitis: a lesion clinically simulating carcinoma. Am J Clin Pathol 1972; 58:642-6.
4. Akbulut S, Yilmaz D, Bakir S. Methotrexate in the man-agement of idiopathic granulomatous mastitis: review of 108 published cases and report of four cases. Breast J 2011;17:661-8.
5. Rubin G, Meerkotter DA. Idiopathic granulomatous mastitis. SA Journal of radiology 2011;15:4-5.
6. Boufettal H, Hermas S, Noun M, et al. Mastite granulo-mateuse idiopathique bilatérale. Imagerie Femme 2009; 19:262-4.
7. Baslaim MM, Khayat HA, Al-Amoudi SA. Idiopathic granulomatous mastitis: A heterogeneous disease with variable clinical presentation. World J Surg 2007;31:1677-81.
8. Lai EC, Chan WC, Ma TK, et al. The role of conservative treatment in idiopathic granulomatous mastitis. Breast J 2005;11:454-6.
9. Patel RA, Rodriguez M. Idiopathic granulomatous mastitis:case report and review of literature. J Gen Intern Med 2010;25:270-3.
10. Brown KL, Tang PH. Postlactational tumoral granulo-matous mastitis: A localized immune phenomenon. Am J Surg 1979;138:326-9.
11. Diesing D, Axt-Fliedner R, Hornung D, et al. Granulo-matous mastits: Review article. Arch Gynecol Obstet 2004;269:233-6.
12. Akcan A, Akyildiz H, Deneme MA, et al. Granulomatous lobular mastitis: A complex diagnostic and therapeutic problem. World J Surg 2006;30:1403-9.
13. Bani-Hani KE, Yaghan RJ, Matalka II, et al. Idiopathic granulomatous mastitis: time to avoid unnecessary mas- tectomies. Breast J 2004;4:318-22.
14. Akbulut S, Arikanoglu Z, Senol A, et al. Is methotrexate an acceptable treatment in the management of idiopathic granulomatous mastitis? Arch Gynecol Obstet 2011; 284:1189-95.
15. Kim J, Tymms KE, Buckingham JM. Methotrexate in the management of granulomatous mastitis. ANZ J Surg 2003;73:247-9.
16. Binesh F, Kargar S, Zahir ST, et al. Idiopathic granulo-matous mastitis, a clinicopathological review of 22 cases. J Clin Exp Pathol 2014;4:157.
17. Lin CH, Hsu CW, Tsao TY, et al. Idiopathic granulomatous mastitis associated with risperidone-induced hyperpro-lactinemia. Diagn Pathol 2012 ;7:2.
18. Fletcher A, Magrath IM, Riddell RH, et al. Granulomatous mastitis: a report of seven cases. J Clin Pathol 1982;35:941-5.
19. Imoto S, Kitaya T, Kodama T, et al. Idiopathic granulo-matous mastitis: case report and review of the literature. Jpn J Clin Oncol 1997;27:274-7.
20. Garcia-Rodiguez JA, Pattullo A. Idiopathic granuloma-tous mastitis: a mimicking disease in a pregnant woman: a case report. BMC Res Notes 2013;6:95.
21. Olsen ML, Dilaveri CA. Idiopathic granulomatous mastitis: a case report of breast abscess. BMJ Case Rep 2011: pii: bcr0520114271. doi: 10.1136/bcr.05.2011.4271.
22. Azlina AF, Ariza Z, Arni T, et al. Chronic granulomatous mastitis: diagnostic and therapeutic considerations. World J Surg 2003;27:515-8.
23. Reddy KM, Meyer CE, Nakdjevani A, et al. Idiopathic granulomatous mastitis in the male breast. Breast J 2005; 11:73.
24. Goldberg J, Baute L, Storey L, et al. Granulomatous mastitis in pregnancy. Obstet Gynecol 2000;96:813-5.
25. Erozgen F, Ersoy YE, Akaydin M, et al. Corticosteroid treatment and timing of surgery in idiopathic granuloma- tous mastitis confusing with breast carcinoma. Breast Cancer Res treat 2010;123:447-52.
26. Han B, Choe YH, Park JM, et al. Granulomatous mastitis mammographic and sonographic appearances. AJR 1999; 173:317-20.
27. Veyssiere C, Vives M, Smadia A. Difficultés diagnostiques de la tuberculose mammaire. Le problème de la mastite granulomateuse. Lille Chir 1967;22:104-9.
28. Raj N, Macmillan RD, Ellis IO, et al. Rheumatologists and breasts: immunosuppressive therapy for granulomatous mastitis. Rheumatology (Oxford) 2004;43:1055-6.
29. Cserni G, Szajki K: Granulomatous lobular mastitis following drug-induced galactorrhoea and blunt trauma. Breast J 1999;5:398-403.
30. Rowe PM. Granulomatous mastitis associated with a pituitary prolactinoma. Br J Clin Pract 1984;38:32-4.
31. Lee JH, Oh KK, Kim EK, et al. Radiologic and clinical features of idiopathic granulomatous lobular mastitis mimicking advanced breast cancer. Yonsei Med J 2006; 47:78-84.
32. Al-Khaffaf B, Knox F, Bundred NJ. Idiopathic granu-lomatous mastitis: a 25-year experience. Amer Col Surg 2008; 206:269-72.
33. Taylor GB, Paviour SD, Musaad S, et al. A clinicopatho-logical review of 34 cases of inflammatory breast disease showing an association between corynebacteria infection and granulomatous mastitis. Pathology 2003;35:109-19.
34. Wilson JP, Massoll N, Marshall J, et al. Idiopathic granu-lomatous mastitis: In search of a therapeutic paradigm. Am Surg 2007;73:798-802.
35. Pandey TS, Mackinnon JC, Bressler L, et al. Idiopathic granulomatous mastitis−a prospective study of 49 women and treatment outcomes with steroid therapy. Breast J 2014;20:258-66.
36. Ayeva-Derman M, Perrotin F, Lefrancq T, et al. Idiopathic granulomatous mastitis. Review of the literature illustrated by 4 cases. J Gynecol Obstet Biol Reprod (Paris) 1999;28:800-7.
37. Vingerhoedt NM, Janssen S, Mravunac M, et al. Granu- lomatous lobular mastitis: A benign abnormality that mimics malignancy. Ned Tijdschr Geneeskd 2008;152:1052-6.
38. Asoglu O, Ozmen V, Karanlik H, et al. Feasibility of surgical management in patients with granulomatous mastitis. Breast J 2005;11:108-14.
39. Gurleyik G, Aktekin A, Aker F, et al. Medical and surgical treatment of idiopathic granulomatous lobular mastitis: A benign inflammatory disease mimicking invasive carcinoma. J Breast Cancer 2012;15:119-23.