Enhanced curcumin solubility by solid dispersion technique reduces fat accumulation in pigs

Abstract

Lifestyle-related diseases such as diabetes mellitus, arteriosclerosis and cardiac diseases are important illness for people around the world. Therefore, there is attempt to produce quality pork with high red meat and low fat content. In this study, the solid dispersion (SD) technique was used to enhance the solubility of curcumin from Turmeric Oleoresin (TO) for use in an animal diet. The SD technique was prepared by mixing TO with carrier (Polyethylene glycol, PEG400) and adsorbent (Magnesium oxide, MgO) at the ratio of 1:1:3 (TOPM). Curcumin was determined using high performance liquid chromatography
(HPLC). The result showed that solubility rate of crude curcumin was increased with carrier and adsorbent (P<0.05). This mixed curcumin was used to reduce fat in pig. Twenty crossbred castrated male pigs (Large White x Landrace x Duroc) with an average weight of 30±3.2 kg were randomly allotted to receive basal diet with curcumin from TOPM at 0, 0.5, 1.0, and 1.5 g /kg of the diet. Blood samples were collected on days 0, 30, and 60. Each pig was raised to 100 kg and all pigs were slaughtered in the slaughter house. Longissimus dorsi (LD) muscles were collected from each pig. Lipid profiles in blood and muscle were
determined. At 60 days of feeding, plasma lipid profile of pigs fed curcumin had higher high-density lipoprotein cholesterol (HDL-C), lower low-density lipoprotein cholesterol (LDL-C), and lower LDL-C: HDL-C ratio than those pigs fed no curcumin. Pigs fed curcumin at 0.5 g/kg diet reduced total cholesterol (TC), and triglycerides (TG) in LD muscles (P<0.05). It concluded that TO mixed with carrier and adsorbent by the SD technique can increase crude curcumin solubility. Top-dressing TOPM in pig diets tend to reduce plasma TC, TG, LDL-C, VLDL-C, and LDL-C: HDL-C ratio.