Outcomes of Antimicrobial Discontinuation Following Guidelines in Patients with Hospital-acquired Pneumonia
The objective of this study was to compare recurrence rates of hospital-acquired pneumonia (HAP) between the group discontinued antimicrobials within 48 hours after their clinical conditions met all the criteria in the antimicrobial discontinuation guidelines (study group) and the group of antimicrobials continuing (control group). Data of the patients admitted to Chiang Kham hospital, Phayao province between January 1, 2013 and June 30, 2016 were collected retrospectively. The clinical conditions in the antimicrobial discontinuation guidelines included 1) body temperature 2) oxygen saturation in peripheral blood 3) characteristics of sputum 4) signs and symptoms of pneumonia. From 181 HAP patients, there were 77 patients whom their clinical data were available for the evaluation according to the guidelines. Most of the patients had late onset HAP. The study demonstrated that recurrence rate of pneumonia was 5.1% (2 from 39 patients) in the study group and 7.9% (3 from 38 patients) in the control group. Due to limited number of patients in the study, the non-inferiority of recurrence rate between study and control groups could not be clearly concluded.
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