Fluorescent Micellar Sensor for Long-Chain Aldehydes Detection

  • Piyanan Pranee นักศึกษา หลักสูตรวิทยาศาสตรมหาบัณทิต สาขาวิชาเคมีอนินทรีย์ คณะวิทยาศาสตร์ จุฬาลงกรณ์มหาวิทยาลัย
  • Boosayarat Tomapatanaget ผู้ช่วยศาสตราจารย์ ภาควิชาเคมี คณะวิทยาศาสตร์ จุฬาลงกรณ์มหาวิทยาลัย
Keywords: Long-chain aldehydes, Micelle, Fluorescence

Abstract

Long-chain aldehyde compounds are regarded as potential biomarkers of many diseases for biomedical applications. Apart from hydrophobic tails of long-chain hydrocarbon and formyl group of long-chain aldehydes, it should perform as surfactants to form the self-assembling organized micelles. In this research, the HZ-doped micellar probes towards aldehyde have been achieved in the concept of incomplete micelle, which was prepared by CTAB and co-surfactant (S1) upon the challenge optimizing task. The micelles could form the complete micelle by long-chain aldehyde as a target analyte based on a self-assembling organized nanomicelles.  The fluorescence intensity of fluorescent dye incorporated in incomplete micelle was enhanced upon the addition of long-chain aldehyde to form the complete micelles. Moreover, the fluorescence change of dye-doped micelles is proportional to the amount of long-chain aldehyde added with the limit of detection (LOD) of 80.38 µM in the linear concentration range of 0.03 to 0.33 mM in 2.5% DMSO/PBS buffer pH 7.4.

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Published
2019-08-09
Section
บทความวิจัย