Antimalarial and Antihypoglycemic Activities of Shallot (Allium ascalonicum) Extract in Plasmodium berghei Infected Mice

Authors

  • Sukanya Chachiyo Department of Clinical Chemistry, Faculty of Medical Technology, Western University, Kanchanaburi, Thailand
  • Wandee Sang-Ngha Department of Clinical Chemistry, Faculty of Medical Technology, Western University, Kanchanaburi, Thailand
  • Somdet Srichairatanakool Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
  • Chairat Uthaipibull National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), Pathumthani, Thailand
  • Voravuth Somsak Department of Clinical Chemistry, Faculty of Medical Technology, Western University, Kanchanaburi, Thailand

Keywords:

Plasmodium berghei, Antimalarial, Antihypoglycemic, shallot, Allium ascalonicum

Abstract

The present study investigated antimalarial and antihypoglycemic activities of aqueous crude extract of shallot (Allium ascalonicum) in Plasmodium berghei infected mice. Groups of ICR mice were treated orally with shallot extract (500, 1000, and 2000 mg/kg) after infection with P. berghei ANKA. Parasitemia and blood glucose levels were determined. At these doses, shallot extract inhibited parasitemia in dose-dependent manner, and could be used as combination treatment with pyrimethamine. In addition, antihypoglycemic activity was observed in dose-dependent fashion in infected mice treated with shallot extracts. In particular, the highest activities of shallot extract were found at dose 2000 mg/kg. These results indicated that aqueous crude extract of shallot has antimalarial and antihypoglycemic activities in P. berghei ANKA infected mice.

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How to Cite

Chachiyo, S., Sang-Ngha, W., Srichairatanakool, S., Uthaipibull, C., & Somsak, V. (2017). Antimalarial and Antihypoglycemic Activities of Shallot (Allium ascalonicum) Extract in Plasmodium berghei Infected Mice. Journal of Health Research, 29(1), 31–36. Retrieved from https://he01.tci-thaijo.org/index.php/jhealthres/article/view/79954

Issue

Vol. 29 No. 1: January - February, 2015

Section

ORIGINAL RESEARCH ARTICLE