Antihypertensive effects of Ma-kiang fruit extract on hypertensive rats

  • ณฐกร คำแก้ว Division of Physiology, School of Medical Sciences, University of Phayao, Phayao Province 56000
  • วาทิตา ผจญภัย Division of Physiology, School of Medical Sciences, University of Phayao, Phayao Province 56000
  • ศศิวิมล รมสาร Division of Physiology, School of Medical Sciences, University of Phayao, Phayao Province 56000
  • ปภาอร เขียวสีมา Division of Physiology, School of Medical Sciences, University of Phayao, Phayao Province 56000
  • วาสนา พิทักษ์พล Faculty of Agriculture and Natural Resources, University of Phayao, Phayao Province 56000
  • กรองกาญจน์ ชูทิพย์ Department of Physiology, Faculty of Medical Science, Naresuan University, Phitsanulok Province 65000
Keywords: Ma-kiang fruit extract, hypertension, Wistar rat, L-NAME

Abstract

The aim of this study was to investigate the acute and chronic effects of Ma-kiang fruit extract on blood pressure in L-NAME induced hypertensive rats. We found significant reduction of blood pressure in a dose-dependent manner through intravenous injection of the extract (20, 40 and 60 mg/kg). Moreover, the chronic oral administration of the extract (500 mg/kg/day) for 6 weeks in hypertensive rats showed the significant attenuation of hypertension, and did not significantly decreased heart rate.

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Published
2019-04-26
How to Cite
1.
คำแก้วณ, ผจญภัยว, รมสารศ, เขียวสีมาป, พิทักษ์พลว, ชูทิพย์ก. Antihypertensive effects of Ma-kiang fruit extract on hypertensive rats. Naresuan Phayao Journal [Internet]. 26Apr.2019 [cited 27Jan.2020];12(1):5-. Available from: https://www.tci-thaijo.org/index.php/journalup/article/view/213565
Section
Research articles