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Depression is an emotional disorder manifested by people experiencing abnormal symptoms of thought, motivation, emotion, and behavior. The disorder is one of the most common mental health problems that can occur at any age. Depression, especially during adolescence, can cause other problems, including deterioration in physical health, decrease in academic performance, difficulty with relationships, and use of illicit substances to cope with personal problems. If depression progresses or intensifies without suitable treatment, it can trigger self-destructive thoughts, leading to an attempted or completed suicide. To ensure that adolescents receive comprehensive and effective care, healthcare professionals need to apply current knowledge and empirical evidence about causes and factors associated with adolescent depression that include awareness of signs/symptoms and diagnostic criteria and models of treatment. Professional nurses can play an important role in taking care of adolescents with depression. Nursing roles are categorized into 2 levels: general registered nurses or psychiatric nurses and advanced psychiatric nurses. The objectives of nursing care for adolescents with depression are to perform suitable screening and diagnosis, provide holistic care to reduce risk of self-harm, and promote modification of negative thoughts, emotions, and behaviors in positive and appropriate directions so they may live with their families and in society.