Histopathological patterns of epithelial ovarian cancer in Prapokklao hospital : A five year retrospective study.

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Wineeya Suknikhom




Background: Ovarian cancer is a leading cause of death, primarily because of delays in diagnosis. Epithelial ovarian cancer (EOC) is the most common histological form of ovarian cancer. The results of treatment depend on the stage and the presence of a residual tumour after surgery.

Objective: The primary objective was to study the histopathological subtype of EOC in patients at Prapokklao Hospital. The secondary objectives included studying the outcomes and factors that affect the outcomes of surgery and treatment in EOC patients.

Materials and methods: This study is a hospital-based retrospective descriptive study which analysed the data of EOC patients in the Division of Obstetrics and Gynaecology at Prapokklao Hospital between January 2011 and December 2016. Incidences of EOC were counted, while the stage, results of surgery and adjuvant treatment after surgery were recorded.

Results: A total of 172 patients were included in the sampling. The most common form identified was serous cystadenocarcinoma (51 cases, 29.7%). The results of surgery were not statistically significant in terms of difference between histopathological subtypes (p = 0.145). Further, there was no difference in treatment method (p = 0.151), metastatic site of disease      (p = 0.364) between less and more aggressive histopathological subtypes. Obesity (AOR = 2.37, 95%CI 1.09-5.15, p = 0.03) and advanced stage (AOR = 4.78, 95%CI 2.11-10.78, p < 0.001) were factors that related to suboptimal surgery in EOC patients.

Conclusions: In this study, serous cystadenocarcinoma was found to be the most common of histopathological subtypes. Histopathological subtypes do not affect the outcome of surgery. Suboptimal surgery was found to be more prevalent in patients with obesity and advanced stages of illness.

Keywords: epithelial ovarian cancer; outcome of surgery; treatment; risk factor 


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นิพนธ์ต้นฉบับ (Original article)


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