Association Between Uric Acid and Arterial Stiffness in General Adults: A Systematic Review and Meta-analysis

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Yan Naung Win Pawin Numthavaj Ammarin Thakkinstian


Background: Arterial stiffness (AS) was a surrogate marker of atherosclerosis and cardiovascular disease and may associate with serum uric acid (UA) level.

Objective: To systematically review the association between serum UA and AS.

Methods: Observational studies that studied the effect of serum UA level and AS in adult population were searched from MEDLINE and Scopus databases since inception to June 30, 2016. Mean differences (MDs) of serum UA level between AS groups and odds ratios of high vs low UA on AS measurement were estimated and pooled.

Results: A total of 61 studies met inclusion criteria, and 44 studies were pooled. Pooled MDs of serum UA between AS vs non-AS measured by carotid femoral pulse wave velocity (cfPWV) and brachial ankle pulse wave velocity (baPWV) in 7 and 5 studies were 0.76 (95% CI, 0.50 - 1.03) mg/dL and 0.58 (95% CI, 0.31 - 0.85) mg/dL, respectively. Three baPWV studies with the pooled odds ratio of high vs low serum UA on AS was 1.49 (95% CI, 1.25 - 1.78). Pooled MDs of AS among high vs low serum UA groups were 62.43 (95% CI, 46.97 - 77.88), 86.20 (95% CI, 35.40 - 136.99), and 32.69 (95% CI, 13.45 - 51.94) cm/s for cfPWV (10 studies), baPWV (4 studies), and carotid radial pulse wave velocity (crPWV) (4 studies), respectively. Pooling beta correlation coefficients of serum UA for AS for cfPWV and baPWV were 2.51 (95% CI, 2.26 - 2.76) and 3.75 (95% CI, 2.24 - 5.25), respectively.

Conclusions: Serum UA was statistically associated with AS measured by cfPWV, baPWV, and crPWV but poolings had high heterogeneity.





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How to Cite
Win, Y., Numthavaj, P., & Thakkinstian, A. (2018). Association Between Uric Acid and Arterial Stiffness in General Adults: A Systematic Review and Meta-analysis. Ramathibodi Medical Journal, 41(2), 90-115.
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