Disease-free Probability and Triple-Negative Breast Cancer

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Published: Mar 30, 2012
DOI: https://doi.org/10.33165/rmj.2012.35.1.117663
Keywords:
Triple-negative breast cancer Local recurrence Distant metastasis Disease-free probability

Main Article Content

Prakasit Chirappapha
Department of Surgery, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
Thongchai Sukarayothin
Department of Surgery, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
Yodying Wasuthit
Department of Surgery, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
Ronnarat Suvikapalornkul
Department of Surgery, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
Panuwat Lertsithichai
Department of Surgery, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
Youwanush Kongdan
Department of Surgery, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand

Abstract

Objective: To compare the probabilities of local recurrence and distant metastasis between women with triple-negative and non- triple negative breast cancers.


Methods: Medical and pathological records of breast cancer patients treated between the years 2002 and 2006 were reviewed.


Results: There were 256 patients with complete data on estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor-2 (HER2) expression determinations. There were 54 patients (21%) with triple-negative (ER-, PR-, HER2 -) cancers. Triple-negative patients were more likely to have larger tumors with higher histologic grade. The median fallow-up time was 4 years. The probabilities of local and distant recurrence were similar between the two groups of patients. Only two factors were independently and significantly associated with overall recurrence: tumor stage and tumor size.


Conclusion: Triple-negative breast cancer did not have a higher risk for both local recurrence and distant metastasis when compared with non-triple negative cancer.

Article Details

How to Cite
1.
Chirappapha P, Sukarayothin T, Wasuthit Y, Suvikapalornkul R, Lertsithichai P, Kongdan Y. Disease-free Probability and Triple-Negative Breast Cancer. Rama Med J [Internet]. 2012 Mar. 30 [cited 2024 Apr. 19];35(1):5-13. Available from: https://he02.tci-thaijo.org/index.php/ramajournal/article/view/117663
Issue
Vol. 35 No. 1 (2012): January-March
Section
Original Articles
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