ZAP-70 Expression and its Prognostic Significance in Childhood B-lineage Acute Lymphoblastic Leukemia

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Published: Sep 24, 2010
Keywords:
ZAP-70 Acute lymphocytic leukemia

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Karan Paisooksantivatana
Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
Chanidapa Iamsa-art
Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
ฺBenjawan Rungsimaporn
Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
Somjai Kanjanapongkul
Department of Pediatrics, Queen Sirikit National Institute of Child Health, Bangkok, Thailand
Surapon Worapongpaiboon
Pathology Unit, Samitivej Hospital, Bangkok, Thailand
Samart Pakakasama
Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand

Abstract

Background: ZAP-70 expression was found in normal human B cell precursors and B lymphoproliferative disorders. Since the level of ZAP-70 expression is prognositic in chronic lymphocytic leukemia, a similar role may be demonstrable in other B-lineage malignancies. The present study investigates the expression of ZAP-70 in B-lineage acute lymphoblastic leukemia and its prognostic significance.


Methods: Thirty-three bone marrow and blood samples were obtained from children newly diagnosed with B-lineage ALL. ZAP-70 was determined using flow cytometry. Correlation between expression of ZAP-70 and clinicobiological presenting features (age, sex, white blood cells) and cytogenetics was performed.


Results: ZAP-70 was expressed in all cases with a wide variation (0.11 - 87.68%). There is no correlation between ZAP-70 expression level and clinicobiological presenting features also the cytogenetics abnormalities was found. Aberrantly high expression of ZAP-70 was found in three cases, two of which had aberrant CD13 and CD33 co-expression.


Conclusions: Aberrantly high expression of ZAP-70 might be associated with certain subgroup (CD13 and CD33 coexpression) of B-lineage ALL.

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How to Cite
1.
Paisooksantivatana K, Iamsa-art C, Rungsimaporn ฺ, Kanjanapongkul S, Worapongpaiboon S, Pakakasama S. ZAP-70 Expression and its Prognostic Significance in Childhood B-lineage Acute Lymphoblastic Leukemia. Rama Med J [Internet]. 2010 Sep. 24 [cited 2024 Apr. 25];33(3):200-8. Available from: https://he02.tci-thaijo.org/index.php/ramajournal/article/view/138599
Issue
Vol. 33 No. 3 (2010): July-September
Section
Original Articles

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