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Severe thalssemia patients require blood transfusion with iron chelation daily to improve quality of long life. The cost of this hypertransfusion program was provided by The National Health Security Office (NHSO) base on the year 2006 was 6,660,000 THB per a 30 years patient. Hematopoietic stem cell transplantation (HSCT) is a new alternation way for curing this disease, but most of people think of high cost and high risk. The objective of this study was estimate the cost of HSCT to compare the cost of hypertransfusion. We examined and calculated the direct costs of treatment in 37 children with Thalassemia underwent 6/6 HLA matchd related donor HSCT at Ramathibodi hospital between 1992 and 2008. A median time of follow-up was 15 months (1.8-63.6 months). The direct costs included the expenses of pre HSCT evaluation, admission for HSCT, complications and other related procedures for out patient follow-up until stopped immuno suppressive agents. Our datas demonstrated that the cost of HSCT was 957,008 THB per transplant which lower than hypertransfusion. Thirty-five patients are disease free survival (95%), being as normal life.
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