Radiation Dosimetry in Non-Hodgkin’s B-Cell Lymphoma Patients Treated with 131I-Rituximab Radioimmunotherapy

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Wirote Changmuang
Arpakorn Kositwattanarerk
Kittipong Thongklam
Kanokon Poonak
Putthiporn Charoenphun
Thanete Doungta

Abstract

Objective: The aim of this study was to calculate a therapeutic dose of 131I-Rituximab after a tracer patient-specific dosimetry based on whole body absorbed dose of 0.75 Gy.


Methods: Eight patients (mean ± S.D. age, 59.0 ± 11.6 years) were given initial tracer activity of 131I-Rituximab intravenously. Whole body images at 10 minutes, 3 days and 6 days were used to generate the Time-activity curve (TAC). TAC was fitted by plotting Log10 of the percentage administered activity remaining with time of scan and was used for calculation of the effective half-life, residence time and therapeutic dose. The organs dose was calculated by MIRDOSE 3.1 software.


Results: The mean effective half-life was 145.7 ± 13.4 hours, whereas the residence time was 210.3 ± 19.4 hours. The mean therapeutic dose was 1.16 ± 0.16 GBq. The mean absorbed dose to liver, lungs, ovaries, red marrow, testes and total body was 0.58 ± 0.05, 0.54 ± 0.05, 0.63 ± 0.06, 0.56 ± 0.05, 0.53 ± 0.05 and 0.54 ± 0.06 mGy/MBq, respectively.


Conclusions: The whole body radiation dose using a patient-specific tracer dose calculation based on whole body absorbed dose of 0.75 Gy was appropriate for therapeutic dose calculation in Radioimmunotherapy (RIT) patient.

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1.
Changmuang W, Kositwattanarerk A, Thongklam K, Poonak K, Charoenphun P, Doungta T. Radiation Dosimetry in Non-Hodgkin’s B-Cell Lymphoma Patients Treated with 131I-Rituximab Radioimmunotherapy. Rama Med J [Internet]. 2017 Jun. 30 [cited 2024 Mar. 29];40(2):8-15. Available from: https://he02.tci-thaijo.org/index.php/ramajournal/article/view/87519
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