การสังเคราะห์สารสีแคโรทีนอยด์ในจุลินทรีย์ Microbial Carotenoid Biosynthesis
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Published:
Dec 18, 2017
Keywords:
สารสีแคโรทีนอยด์ Carotenoid Pigment จุลินทรีย์ Microorganism วิถีการสังเคราะห์แคโรทีนอยด์ Carotenoid Biosynthesis Pathway
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Abstract
บทคัดย่อ
สารสีกลุ่มแคโรทีนอยด (Carotenoid) จัดเป็นสารที่มีมูลค่าและมีความสำคัญต่ออุตสาหกรรมหลายประเภท ปัจจุบันการผลิตแคโรทีนอยด์สามารถทำได้โดยการสังเคราะห์ทางเคมีและการสกัดจากพืชธรรมชาติ ซึ่งพบปัญหาในเรื่องของคุณภาพผลิตภัณฑ์ที่ขึ้นอยู่กับฤดูกาลและสภาพภูมิอากาศ และยังพบปัญหาในส่วนของต้นทุนการผลิตที่ไม่สอดคล้องกับปริมาณผลิตภัณฑ์ ดังนั้นการศึกษาวิจัยเพื่อใช้จุลินทรีย์ในการผลิต จึงมีความสำคัญเป็นอย่างมาก โดยเฉพาะอย่างยิ่งการควบคุมคุณภาพให้คงที่ รวมไปถึงการลดต้นทุนการผลิต โดยการเลือกใช้วัสดุราคาถูกหรือวัสดุเหลือทิ้งจากอุตสาหกรรมเป็นสารตั้งต้นในการผลิตผลิตภัณฑ์แคโรทีนอยด์ ในบทความนี้ได้กล่าวถึงการสังเคราะห์แคโรทีนอยด์ในจุลินทรีย์ทั้งเชื้อรา แบคทีเรีย และสาหร่ายที่ใช้ในระดับอุตสาหกรรม และยังได้รายงานเกี่ยวกับวิถีการสังเคราะห์แคโรทีนอยด์ในจุลินทรีย์รวมทั้งยีนและเอนไซม์ที่เกี่ยวข้อง ทั้งนี้เพื่อนำไปสู่การประยุกต์ใช้ความรู้ทางเทคโนโลยีชีวภาพร่วมกับการศึกษาพัฒนากระบวนการเพาะเลี้ยงจุลินทรีย์ในการเพิ่มปริมาณแคโรทีนอยด์และนำไปสู่การผลิตในระดับอุตสาหกรรมต่อไปในอนาคต
Abstract
Carotenoid pigments serve as essential and more valuable molecules in several industries. Nowadays, commercial carotenoid is completely synthesized by chemical process and natural plant extraction. This results in variation of product quality based on season and climate change as well as low yield with high production costs. Hence, the study of the microbial carotenoid production is very crucial, especially for constant control of product quality and cost reduction by using low-cost substrates from industrial waste. This article focused on the industrial carotenoid synthesis through the potential microorganism including fungi, bacteria and algae. In addition, the review also highlights the regulation mechanism of carotenoid biosynthesis pathway in term of genes and related enzymes as well as modern biotechnology application to increase the efficiency of carotenoid production level for industrial production in the future.
Article Details
How to Cite
[1]
เอี่ยมสะอาด ป., “การสังเคราะห์สารสีแคโรทีนอยด์ในจุลินทรีย์ Microbial Carotenoid Biosynthesis”, RMUTI Journal, vol. 10, no. 3, pp. 118–131, Dec. 2017.
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บทความวิชาการ (Academic article)
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[18] Bhosale P. and Bernstein P.S. (2005). Microbial Xanthophylls. Applied Microbiology and Biotechnology. Vol. 68. No. 4. pp. 445-455. DOI: 10.1007/s00253-005-0032-8
[19] Kirti K., Amita S., Priti S., Kumar A.M. and Jyoti S. (2014). Colorful World of Microbes: Carotenoids and their Applications. Advances in Biology. Vol. 2014. Article ID 837891. pp. 1-13. DOI: 10.1155/2014/837891
[20] Britton G. (1993). Structure and Nomenclature of Carotenoids. Carotenoids in Photosynthesis. Netherlands : Chapman and Hall.
[21] Schmidt-Dannert C. (2000). Engineering Novel Carotenoids in Microorganisms. Current Opinion in Biotechnology. Vol. 11. No. 3. pp. 255-261
[22] Paniagua-Michel J., Olmos-Soto J. and Ruiz M.A. (2012). Pathways of Carotenoid Biosynthesis in Bacteria and Microalgae. Methods in Molecular Biology. Vol. 892. pp. 1-13. DOI: 10.1007/978-1-61779-879-5_1
[23] Yan Y., Zhu Y.H., Jiang J.G. and Song D.L. (2005). Cloning and Sequence Analysis of the Phytoene Synthase Gene from a Unicellular Chlorophyte, Dunaliella salina. Journal of Agricultural and Food Chemistry. Vol. 53. No. 5. pp. 1466-1469
[24] Li S. and Li L. (2008). Carotenoid Metabolism: Biosynthesis, Regulation, and Beyond. Journal of Integrative Plant Biology. Vol. 50. No. 7. pp. 778-785
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