Clinical Outcomes and Risk Factors Affecting on Clinical Outcomes in Patients with

  • Wandee Sumret Pharmacy department, Huahin Hospital, Prachuap Khiri Khan, Thailand
  • Kanokwan Limsubjaroen Department of Pharmacy, Silpakorn University, Nakhon Pathom, Thailand
  • Nattaporn Ruangnara Department of Pharmacy, Silpakorn University, Nakhon Pathom, Thailand
  • Parada Sujarittham Department of Pharmacy, Silpakorn University, Nakhon Pathom, Thailand
  • Ploypailin Mulmek Department of Pharmacy, Silpakorn University, Nakhon Pathom, Thailand
  • Weerayuth Saelim Department of Pharmacy, Silpakorn University, Nakhon Pathom, Thailand
  • Wichai Santimaleeworagun Department of Pharmacy, Silpakorn University, Nakhon Pathom, Thailand
Keywords: Acinetobacter baumannii, Carbapenem resistant, Clinical outcomes, Risk factors

Abstract

This study aimed to determine percentage of 30-days mortality and treatment failure in patients infected with carbapenem-resistant Acinetobacterbaumanii (CRAB) and to evaluate predictive factors associated with 30-days mortality and treatment failure. This retrospective study collected data from medical records of patients hospitalized at Huahin Hospital from January to December 2012. Seventy three patients with CRAB infections met eligible criteria, 57.5 and 61.6% were death and treatment failure rate, respectively. Risk factors associated with 30-days mortality were appropriate antimicrobial therapy (OR 0.22; 95% CI 0.08-0.62) and shock (OR 5.80; 95% CI 1.19-28.20), whereas the appropriate antimicrobial therapy (OR 0.11;95%CI 0.03-0.37) and shock (OR 10.97;95%CI 1.35-89.34) were also predictors for treatment failure. In multivariate analysis, a factor associated with 30-days mortality and treatment failure remained the appropriate antimicrobial therapy. In conclusion, the appropriate antimicrobial treatment was a strategy associated with better treatment outcomes in patients with CRAB infections.

Published
2014-01-13
Section
Research Articles