The Evaluation of Posterior Cingulate Gyrus by Diffusion Tensor Imaging in Alzheimer’s Disease Patients Compared with Normal Control Subjects

Authors

  • Chanon Ngamsombat Department of Radiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok
  • Thanapat Dechasasawat Department of Radiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok
  • Jitsupa Wongsripuemtet Department of Radiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok
  • Panida Charnchaowanish Department of Radiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok
  • Weerasak Muangpaisan Department of Preventive and Social Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
  • Orasa Chawalparit Department of Radiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok

DOI:

https://doi.org/10.33192/Smj.2019.18

Keywords:

Diffusion tensor imaging; Posterior cingulate gyrus; Alzheimer’s disease

Abstract

Objective: Posterior cingulate gyrus atrophy is found in early clinical stage of Alzheimer’s disease (AD) patients.1
Diffusion tensor imaging (DTI) can be used for evaluating microstructure change in brain parenchyma.2 Our
objective was to compare the microstructural change at posterior cingulate gyrus between AD patients and normal
control subjects by using DTI.
Methods: The retrospective review of 23 AD patients, diagnosed by NINCDS-ADRDA with available MRI data
including DTI, and 19 normal control subjects was performed. The DTI parameters of posterior cingulate gyrus of
each group were analyzed and compared.
Results: The mean diffusivity (MD), axial diffusivity and radial diffusivity (RD) of posterior cingulate gyrus were
significantly increased in AD patients compared with normal control subjects (p value <0.001, <0.001, <0.001,
respectively). The fractional anisotropy (FA) was slightly decreased in AD patients compared with normal control
subjects but did not reach statistical significance (p value=0.71).
Conclusion: Microstructural change at posterior cingulate gyrus demonstrated by DTI parameters including MD,
axial diffusivity and RD were significantly different between AD patients and normal control subjects. These results
were probably helpful for early diagnosis, evaluation, and follow up of the AD patients as correlate with clinical
findings.

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Published

28-03-2019

How to Cite

Ngamsombat, C., Dechasasawat, T., Wongsripuemtet, J., Charnchaowanish, P., Muangpaisan, W., & Chawalparit, O. (2019). The Evaluation of Posterior Cingulate Gyrus by Diffusion Tensor Imaging in Alzheimer’s Disease Patients Compared with Normal Control Subjects. Siriraj Medical Journal, 71(2), 117–122. https://doi.org/10.33192/Smj.2019.18

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Section

Original Article