The Malignant Potential in Adult Choledochal Cysts; an Awareness Issue

Pholasith Sangserestid; Chutwichai Tovikkai; Yongyut Sirivatanauksorn; Prawat Kositamongkol; Prawej Mahawithitwong; Wethit Dumronggittigule; Somchai Limsrichamrern

doi:10.33192/Smj.2019.69

The Malignant Potential in Adult Choledochal Cysts; an Awareness Issue

Authors

Pholasith Sangserestid Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700 http://orcid.org/0000-0002-5975-1840
Chutwichai Tovikkai Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700 http://orcid.org/0000-0002-4412-0528
Yongyut Sirivatanauksorn Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700 http://orcid.org/0000-0001-7520-8832
Prawat Kositamongkol Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700 http://orcid.org/0000-0002-8797-9658
Prawej Mahawithitwong Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700 http://orcid.org/0000-0001-9151-8929
Wethit Dumronggittigule Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700
Somchai Limsrichamrern Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700 http://orcid.org/0000-0003-4350-0737

DOI:

https://doi.org/10.33192/Smj.2019.69

Keywords:

Cholangiocarcinoma; choledochal cyst; malignancy; prognosis factors; risk factors

Abstract

Objective: Although still uncommon, choledochal cysts (CCs) are more frequently found in Asians than Caucasians. The incidence of malignancy associated with these cysts and the surgical outcomes have not been reported in Thailand.
Methods: A retrospective review was performed of 48 adult CC patients who underwent surgery January 2005–December 2015. Their clinical data and outcomes were analyzed.
Results: There were 31 (64.6%) female patients, with a female-to-male ratio of 1.8:1. The mean age + SD at diagnosis was 40.5 + 17.4 years. Using the modified Todani classification, 32 patients (66.7%) had a type I CC, one (2.1%) had type II, twelve (25.0%) had type IV, and three (6.3%) had type V. Twelve patients (25%) had a malignant tumor: eleven had synchronous cancer at surgery, while one with CC type I developed metachronous intrahepatic cholangiocarcinoma during the follow-up. The cholangiocarcinoma was inside the CC in 6 cases, intrahepatic in three, perihilar in two, and distal in one. The 5-year overall survival of the cohort was 68%. The factor affecting the overall survival was the coexisting cancer (p < 0.001). The 1-year and 5-year overall survival rates were 58.3% and 20%, respectively, for patients with cancer, but 96.7% and 88.4% for patients without cancer.
Conclusion: The adult choledochal cysts had a high incidence of associated malignancy. Factors predicting coexisting malignancy were an age above 40 years and a significant weight loss. If cancer occurred, the overall survival was significantly poor. Even after definitive surgery, patients still need life-long surveillance for cancer.

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Published

18-11-2019

How to Cite

Sangserestid, P., Tovikkai, C., Sirivatanauksorn, Y., Kositamongkol, P., Mahawithitwong, P., Dumronggittigule, W., & Limsrichamrern, S. (2019). The Malignant Potential in Adult Choledochal Cysts; an Awareness Issue. Siriraj Medical Journal, 71(6), 466–471. https://doi.org/10.33192/Smj.2019.69

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Issue

Vol. 71 No. 6 (2019): November-December

Section

Original Article

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