Antimicrobial Agents Produced by Fusarium sp., an Endophytic Fungus of Salvinia cuculata Roxb & Bory
Article Sidebar
Main Article Content
Abstract
Isolation of the chemical constituents from an endophytic fungus Fusarium sp. , isolated from
Salvinia cucullata Roxb. & Bory, yielded four compounds: “Sydoxanthone A (1)”, “13-O-acetylsydowinin B (2)”,
“Secalonic Acid A (3)” and “Emodin (4)”. Antimicrobial activity of isolated compounds against four bacteria,
S. aureus (SA), Methicillin - resistant S. aureus, P. aeruginosa ATCC27853 (MRSA SK1) and E. coli (EC)
and against two yeast, Candida albicans ATCC90028 (CA90028) and Cryptococcus neoformans ATCC90112
Flucytosine – resistant (CN90112) was determined. The results were found that compound 3 had good
antibacterial activity against SA, MRSA SK1, PA and EC and antiyeast activity against CA90028 and
CN90112 with the MIC 25.1, 25.1, 25.1, 50.2, 50.2 and 50.2 μ M, respectively. Compound 1 exhibited
moderate activities against bacteria SA, MRSA SK1 and PA at 82.2 μM. However compound 2 and 4 showed
weak activities to inhibit the growth of bacteria and yeast.
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
References
Endophytic Fungi with Anticancer Activity. European Journal of Medicinal Chemistry, 156, 316-343.
[2] Hussain, H., Kliche-Spory, C., Al-Harrasi, A., Al-Rawahi, A., Abbas, G., Robert, I., Schulz, B., Krohn, K., &
Shah, A. ( 2014) . Antimicrobial Constituents from Three Endophytic Fungi. Asian Pacific Journal of Tropical Medicine, 7, 224-227.
[3] Zhang, G., Sun, S., Zhu, T., Lin, Z., Gu, J., Li, D., & Gu, Q. (2011). Antiviral Isoindolone Derivertives from an
Endophytic Fungus Emericella sp. Associated with Aegiceras corniculatum. Phytochemistry, 72,
1436-1442.
[ 4] Uma Anitha, K. P. G. & Mythili, S. ( 2017) . Antioxidant and Hepatoprotective Potentials of Novel
Endophytic Fungus Achaetomium sp., from Euphorbia hirta. Asian Pacific Journal of Tropical
Medicine, 10(6), 588-593.
[5] Guangfeng, L., Ping, W., Jinghua, X., Lan, L., Hanxiang, L. & Xiaoyi, W. (2018). Asperimides A–D, Anti-
Inflammatory Aromatic Butenolides from a Tropical Endophytic Fungus. Aspergillus terreus. Fitoterapia, 131, 50-54.
[6] Na, G., Zhi-Chun, S., Pei, Y., Jie, L., Kai-Li, J., Ling-Yi, K., & Ming-Hua, Y. (2017). Alkaloids from the
Endophytic Fungus Penicillium brefeldianum & Their Cytotoxic Activities. Chinese Chemical Letters, 28, 1194-1199.
[7] Nasima, K., Farhana, Afrozb, M., Nadira, B., Satyajit, R., Ronyb, S., Sharminb, F., Monib, C., Mahmood,
H., Koushik, S., & Hossain, S. (2018). Endophytic Fusarium solani: A Rich Source of Cytotoxic and Antimicrobial Napthaquinone and Aza-anthraquinone Derivatives. Toxicology Reports, 5, 970-976.
[8] Wen-Jie, X., Hui-Qin, C., Hao, W., Cai-Hong, C., Wen-Li, M., & Hao-Fu, D. (2018). New Secondary
Metabolites from the Endophytic Fungus Fusarium sp. HP-2 Isolated from “Qi-Nan” Agarwood. Fitoterapia,
130, 180-183.
[ 9] Boonyaketgoson, S., Trisuwan, K., Bussaban, B., Rukachaisirikul, V., & Phongpaichit, S. ( 2015) .
Isochromanone Derivatives from the Endophytic Fungus Fusarium sp. PDB51F5. Tetrahedron
Letters, 56, 5076-5078.
[10] Sabrin, R. M. I., Hossam M. A., Gamal A. M., & Samir A. R. (2016). Integracides H-J: New Tetracyclic
Triterpenoids from the Endophytic Fungus Fusarium sp. Fitoterapia, 112, 161-167.
[11] Sabrin R. M. I., Gamal A. M., & Samir A. R. (2016). Integracides F and G: New Tetracyclic Triterpenoids
from the Endophytic Fungus Fusarium sp. Phytochemistry Letters, 15, 125-130.
[12] Song, X. Q., Zhang, X., Han, Q. J., Li, X.B., Li, G., Li, R. J., Jiao, Y., Zhou, J. C., Lou, H. X. (2015).
Xanthone derivatives from Aspergillus sydowii, an endophytic fungus from the liverwort
Scapania ciliata S. Lac and their immunosuppressive activities. Phytochemistry Letters, 6 (3),
318-321.
[13] Elnaggar, M. S., Ebada, S. S., Ashour, M. L., Ebrahim, W., Muller, E. G., Mandi, A., Kurtan, T., Singab, A.,
Lin,W., Liu, Z. & Proksch, P. (2016). Xanthones and Sesquiterpene Derivatives from a
Marine-Derived Fungus Scopulariopsis sp. Tetrahedron, 72, 2411-2419.
[14] Zhai, A., Zhang, Y., Zhu, X., Liang, J., Wang, X., Lin, Y., & Chen, R. (2011). Secalonic Acid a
Reduced Colchicines Cytotoxicity through Suppression of JNK, p38 MAPKs and Calcium influx.
Neurochemistry International, 58, 85-91.
[15] Kim, M. O., Park, Y. S., Nho, Y. H., Yun, S. K., Kim, Y., Jung, E., Paik, J. K., Kim, M., Cho, H., & Lee, J.
(2016). Emodin Isolation from Polygoni Multiflori Ramulus Inhibits Melanogenesis Through
the Liver X Receptor-Mediated Pathway. Chemico-Biological Interactions, 250, 78-84.