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This research aims to study the creation of teams to develop open innovation strategy between universities and the Southern region’s rubber export entrepreneurs to enhance their capability for research and development. The obtained data were based on in-depth interviews of the rubber entrepreneurs, business incubator agents and representatives of the teams who have worked together to develop systems of relationships and team building strategies leading to open innovation. The research results identified the relationships among many factors that affect the team production: the government policies and support, the role of universities, strategy formulation of entrepreneurs, success factors and the team performance itself. This research results offer a model of team building for various entrepreneurs; and in particular, those entrepreneurs who export rubber-based products affecting the upgrading of the midstream to downstream industries or develop existing products to maintain a position in industrial competition.
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